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Comparative Study on Different Skin Pruritus Mouse Models

The animal model is an important tool to study the mechanism of disease formation. Different animal models of pruritus have been adopted based on the purpose of researchers in the study of the itching mechanism. Although the symptoms of various models are quite different, scratching behavior is a ke...

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Autores principales: Donglang, Guan, Tongtong, Liu, Dan, Chen, Chan, Zhu, Changming, Wang, Guang, Yu, Yan, Yang, Zongxiang, Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940346/
https://www.ncbi.nlm.nih.gov/pubmed/33708782
http://dx.doi.org/10.3389/fmed.2021.630237
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author Donglang, Guan
Tongtong, Liu
Dan, Chen
Chan, Zhu
Changming, Wang
Guang, Yu
Yan, Yang
Zongxiang, Tang
author_facet Donglang, Guan
Tongtong, Liu
Dan, Chen
Chan, Zhu
Changming, Wang
Guang, Yu
Yan, Yang
Zongxiang, Tang
author_sort Donglang, Guan
collection PubMed
description The animal model is an important tool to study the mechanism of disease formation. Different animal models of pruritus have been adopted based on the purpose of researchers in the study of the itching mechanism. Although the symptoms of various models are quite different, scratching behavior is a key indicator. Therefore, it is necessary to find an animal model that can quickly induce animal scratching and maintain the stability of scratching behavior. In this study, we compared animal models of pruritus induced by four substances and found that the scratching behavior of mice induced by urushiol not only reached the plateau stage quickly but also showed more stability in the plateau phase than that induced by 2,4-dinitrofluorobenzene, oxazolone, and imiquimod. Meanwhile, in the animal model induced by urushiol, the changes of epidermal thickening and inflammatory cell aggregation were also more obvious. In addition, pruritus induced by urushiol is prevalent all over the world, especially in the United States and Europe, involving outdoor groups such as firefighters, forest loggers, and farmers. Therefore, we believe that the urushiol-induced animal model is an ideal choice for the study of the itch formation mechanism and the development of antipruritic drugs.
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spelling pubmed-79403462021-03-10 Comparative Study on Different Skin Pruritus Mouse Models Donglang, Guan Tongtong, Liu Dan, Chen Chan, Zhu Changming, Wang Guang, Yu Yan, Yang Zongxiang, Tang Front Med (Lausanne) Medicine The animal model is an important tool to study the mechanism of disease formation. Different animal models of pruritus have been adopted based on the purpose of researchers in the study of the itching mechanism. Although the symptoms of various models are quite different, scratching behavior is a key indicator. Therefore, it is necessary to find an animal model that can quickly induce animal scratching and maintain the stability of scratching behavior. In this study, we compared animal models of pruritus induced by four substances and found that the scratching behavior of mice induced by urushiol not only reached the plateau stage quickly but also showed more stability in the plateau phase than that induced by 2,4-dinitrofluorobenzene, oxazolone, and imiquimod. Meanwhile, in the animal model induced by urushiol, the changes of epidermal thickening and inflammatory cell aggregation were also more obvious. In addition, pruritus induced by urushiol is prevalent all over the world, especially in the United States and Europe, involving outdoor groups such as firefighters, forest loggers, and farmers. Therefore, we believe that the urushiol-induced animal model is an ideal choice for the study of the itch formation mechanism and the development of antipruritic drugs. Frontiers Media S.A. 2021-02-23 /pmc/articles/PMC7940346/ /pubmed/33708782 http://dx.doi.org/10.3389/fmed.2021.630237 Text en Copyright © 2021 Donglang, Tongtong, Dan, Chan, Changming, Guang, Yan and Zongxiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Donglang, Guan
Tongtong, Liu
Dan, Chen
Chan, Zhu
Changming, Wang
Guang, Yu
Yan, Yang
Zongxiang, Tang
Comparative Study on Different Skin Pruritus Mouse Models
title Comparative Study on Different Skin Pruritus Mouse Models
title_full Comparative Study on Different Skin Pruritus Mouse Models
title_fullStr Comparative Study on Different Skin Pruritus Mouse Models
title_full_unstemmed Comparative Study on Different Skin Pruritus Mouse Models
title_short Comparative Study on Different Skin Pruritus Mouse Models
title_sort comparative study on different skin pruritus mouse models
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940346/
https://www.ncbi.nlm.nih.gov/pubmed/33708782
http://dx.doi.org/10.3389/fmed.2021.630237
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