Cargando…

Cannabidiol induces autophagy via ERK1/2 activation in neural cells

Autophagy is a lysosomal catabolic process essential to cell homeostasis and is related to the neuroprotection of the central nervous system. Cannabidiol (CBD) is a non-psychotropic phytocannabinoid present in Cannabis sativa. Many therapeutic actions have been linked to this compound, including aut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vrechi, Talita A. M., Leão, Anderson H. F. F., Morais, Ingrid B. M., Abílio, Vanessa C., Zuardi, Antonio W., Hallak, Jaime Eduardo C., Crippa, José Alexandre, Bincoletto, Claudia, Ureshino, Rodrigo P., Smaili, Soraya S., Pereira, Gustavo J. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940388/ https://www.ncbi.nlm.nih.gov/pubmed/33686185 http://dx.doi.org/10.1038/s41598-021-84879-2

Ejemplares similares

Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy
por: Peres, Fernanda F., et al.
Publicado: (2016)

Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?
por: Loss, Cássio Morais, et al.
Publicado: (2021)

Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol
por: Crippa, José A. S., et al.
Publicado: (2016)

Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
por: Peres, Fernanda F., et al.
Publicado: (2018)

Autophagy and intermittent fasting: the connection for cancer therapy?
por: Antunes, Fernanda, et al.
Publicado: (2018)

Cannabidiol Administered During Peri-Adolescence Prevents Behavioral Abnormalities in an Animal Model of Schizophrenia
por: Peres, Fernanda F., et al.
Publicado: (2018)

Glutamate induces autophagy via the two-pore channels in neural cells
por: Pereira, Gustavo J.S., et al.
Publicado: (2016)

Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats
por: Peres, Fernanda F., et al.
Publicado: (2016)

Effects of ICI 182,780, an ERα and ERβ antagonist, and G-1, a GPER agonist, on autophagy in breast cancer cells
por: Muler, Mari Luminosa, et al.
Publicado: (2020)

Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19
por: Pereira, Gustavo José da Silva, et al.
Publicado: (2021)

Cannabidiol for the treatment of crack-cocaine craving: an exploratory double-blind study
por: de Meneses-Gaya, Carolina, et al.
Publicado: (2020)

Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma
por: Vuolo, Francieli, et al.
Publicado: (2015)

The anxiolytic effect of cannabidiol depends on the nature of the trauma when patients with post-traumatic stress disorder recall their trigger event
por: Bolsoni, Lívia Maria, et al.
Publicado: (2022)

No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
por: Linares, Ila M. P., et al.
Publicado: (2018)

Evaluation of the role of the cannabidiol system in an animal model of ischemia/reperfusion kidney injury
por: Soares, Rodrigo Zon, et al.
Publicado: (2015)

Biological bases for a possible effect of cannabidiol in Parkinson’s disease
por: Ferreira-Junior, Nilson C., et al.
Publicado: (2019)

Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload
por: da Silva, Vanessa Kappel, et al.
Publicado: (2018)

Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life
por: Zuardi, Antonio W., et al.
Publicado: (2017)

NAADP-Evoked Ca(2+) Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
por: Pereira, Cássia Arruda de Souza, et al.
Publicado: (2023)

Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain
por: Levin, Raquel, et al.
Publicado: (2014)

Systemic Chronic Treatment with Cannabidiol in Carioca High- and Low-Conditioned Freezing Rats in the Neuropathic Pain Model: Evaluation of Pain Sensitivity
por: Macêdo-Souza, Carolina, et al.
Publicado: (2023)

Maternal administration of cannabidiol promotes an anti-inflammatory effect on the intestinal wall in a gastroschisis rat model
por: Callejas, G.H., et al.
Publicado: (2018)

17.4 POSSIBLE MECHANISMS INVOLVED IN THE ANTIPSYCHOTIC EFFECTS OF CANNABIDIOL (CBD)
por: Crippa, Jose Alexandre, et al.
Publicado: (2018)

Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
por: Crippa, José A., et al.
Publicado: (2018)

Adverse Effects of Oral Cannabidiol: An Updated Systematic Review of Randomized Controlled Trials (2020–2022)
por: Souza, José Diogo R., et al.
Publicado: (2022)

Marijuana, feijoada and the debate on drug legalization
por: Crippa, José A. S., et al.
Publicado: (2013)

Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13
por: Falvella, Ana Caroline Brambilla, et al.
Publicado: (2021)

A Conversion of Oral Cannabidiol to Delta9-Tetrahydrocannabinol Seems Not to Occur in Humans
por: Nahler, Gerhard, et al.
Publicado: (2017)

Corrigendum: Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13
por: Falvella, Ana Caroline Brambilla, et al.
Publicado: (2021)

Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
por: Crippa, José A., et al.
Publicado: (2021)

Lack of Autophagy Induction by Lithium Decreases Neuroprotective Effects in the Striatum of Aged Rats
por: Costa, Angelica Jardim, et al.
Publicado: (2021)

Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects
por: Breuer, Aviva, et al.
Publicado: (2016)

Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy
por: Do Val-da Silva, Raquel A., et al.
Publicado: (2017)

Correction: Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects
por: Breuer, Aviva, et al.
Publicado: (2016)

Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations
por: Souza, José Diogo S., et al.
Publicado: (2022)

Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats
por: Genaro, Karina, et al.
Publicado: (2017)

Dr. Raphael Mechoulam, cannabis and cannabinoids research pioneer (November 5, 1930–March 9, 2023) and his legacy for Brazilian pharmacology
por: Crippa, José Alexandre S., et al.
Publicado: (2023)

Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test
por: Linares, Ila M., et al.
Publicado: (2018)

Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze
por: Fabris, Débora, et al.
Publicado: (2022)

F198. EFFECTS OF CANNABINOIDS ON A HUMAN OLIGODENDROCYTE CULTURE: IMPLICATIONS FOR SCHIZOPHRENIA
por: Almeida, Valéria, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dkjuhuuehj94lbpn94jam6p1io