Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity

Fc-less bispecific T-cell engagers have reached the immuno-oncology market but necessitate continual infusion due to rapid clearance from the circulation. This work introduces a programmable serum half-life extension platform based on fusion of human albumin sequences engineered with either null (NB...

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Detalles Bibliográficos
Autores principales: Mandrup, Ole A., Ong, Sui Ching, Lykkemark, Simon, Dinesen, Anders, Rudnik-Jansen, Imke, Dagnæs-Hansen, Niels Frederik, Andersen, Jan Terje, Alvarez-Vallina, Luis, Howard, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940400/
https://www.ncbi.nlm.nih.gov/pubmed/33686177
http://dx.doi.org/10.1038/s42003-021-01790-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940400/
https://www.ncbi.nlm.nih.gov/pubmed/33686177
http://dx.doi.org/10.1038/s42003-021-01790-2

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