Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors

It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little is known about how BRCA1 loss-of-function (LOF) and concomitant mutations affect th...

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Detalles Bibliográficos
Autores principales: Bach, Karsten, Pensa, Sara, Zarocsinceva, Marija, Kania, Katarzyna, Stockis, Julie, Pinaud, Silvain, Lazarus, Kyren A., Shehata, Mona, Simões, Bruno M., Greenhalgh, Alice R., Howell, Sacha J., Clarke, Robert B., Caldas, Carlos, Halim, Timotheus Y. F., Marioni, John C., Khaled, Walid T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940427/
https://www.ncbi.nlm.nih.gov/pubmed/33686070
http://dx.doi.org/10.1038/s41467-021-21783-3

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