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Influence of Pelvic Intensity-Modulated Radiation Therapy With Concurrent Cisplatin-Based Chemotherapy of Cervical Cancer on the Vaginal Microbiome

Pelvic intensity-modulated radiation therapy (IMRT) combined with concurrent chemotherapy is an effective treatment for cervical cancer; however, radiation resistance impairs its clinical benefit. The vaginal microbiome plays an important but poorly understood role in cancer radiochemotherapy. In th...

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Autores principales: Jiang, Li, Li, Bo, Zhang, Yong, Ma, Shanshan, Liu, Chang, Liang, Feifei, Wei, Zhuxin, Huang, Tingting, Wang, Rensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940522/
https://www.ncbi.nlm.nih.gov/pubmed/33708628
http://dx.doi.org/10.3389/fonc.2021.615439
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author Jiang, Li
Li, Bo
Zhang, Yong
Ma, Shanshan
Liu, Chang
Liang, Feifei
Wei, Zhuxin
Huang, Tingting
Wang, Rensheng
author_facet Jiang, Li
Li, Bo
Zhang, Yong
Ma, Shanshan
Liu, Chang
Liang, Feifei
Wei, Zhuxin
Huang, Tingting
Wang, Rensheng
author_sort Jiang, Li
collection PubMed
description Pelvic intensity-modulated radiation therapy (IMRT) combined with concurrent chemotherapy is an effective treatment for cervical cancer; however, radiation resistance impairs its clinical benefit. The vaginal microbiome plays an important but poorly understood role in cancer radiochemotherapy. In this study, we investigated the effects of treatment on the overall composition and alteration of the vaginal microbiome in patients receiving pelvic IMRT with concurrent cisplatin-based chemotherapy. We collected samples from twenty patients with cervical cancer and six healthy controls and performed 16S rRNA sequencing. Vaginal microbial composition analysis revealed significant differences between the two groups, but no significant differences between radiation treatment time points. However, the relative abundances of Gammaproteobacteria, Gemmatimonadetes, Gemmatimonadales, Pseudomonadales, Gemmatimonadaceae, Rikenellaceae, Acinetobacter, Desulfovibrio, Prevotella 9, Rikenellaceae RC9 gut group, Turicibacter, and the metagenome increased with time. The results encourage further study into the effects of the vaginal microbiome on cervical cancer treatment strategies, especially radiochemotherapy. Better understanding of these effects could inform new therapeutic approaches to enhance the efficacy of radiochemotherapy.
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spelling pubmed-79405222021-03-10 Influence of Pelvic Intensity-Modulated Radiation Therapy With Concurrent Cisplatin-Based Chemotherapy of Cervical Cancer on the Vaginal Microbiome Jiang, Li Li, Bo Zhang, Yong Ma, Shanshan Liu, Chang Liang, Feifei Wei, Zhuxin Huang, Tingting Wang, Rensheng Front Oncol Oncology Pelvic intensity-modulated radiation therapy (IMRT) combined with concurrent chemotherapy is an effective treatment for cervical cancer; however, radiation resistance impairs its clinical benefit. The vaginal microbiome plays an important but poorly understood role in cancer radiochemotherapy. In this study, we investigated the effects of treatment on the overall composition and alteration of the vaginal microbiome in patients receiving pelvic IMRT with concurrent cisplatin-based chemotherapy. We collected samples from twenty patients with cervical cancer and six healthy controls and performed 16S rRNA sequencing. Vaginal microbial composition analysis revealed significant differences between the two groups, but no significant differences between radiation treatment time points. However, the relative abundances of Gammaproteobacteria, Gemmatimonadetes, Gemmatimonadales, Pseudomonadales, Gemmatimonadaceae, Rikenellaceae, Acinetobacter, Desulfovibrio, Prevotella 9, Rikenellaceae RC9 gut group, Turicibacter, and the metagenome increased with time. The results encourage further study into the effects of the vaginal microbiome on cervical cancer treatment strategies, especially radiochemotherapy. Better understanding of these effects could inform new therapeutic approaches to enhance the efficacy of radiochemotherapy. Frontiers Media S.A. 2021-02-23 /pmc/articles/PMC7940522/ /pubmed/33708628 http://dx.doi.org/10.3389/fonc.2021.615439 Text en Copyright © 2021 Jiang, Li, Zhang, Ma, Liu, Liang, Wei, Huang and Wang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Jiang, Li
Li, Bo
Zhang, Yong
Ma, Shanshan
Liu, Chang
Liang, Feifei
Wei, Zhuxin
Huang, Tingting
Wang, Rensheng
Influence of Pelvic Intensity-Modulated Radiation Therapy With Concurrent Cisplatin-Based Chemotherapy of Cervical Cancer on the Vaginal Microbiome
title Influence of Pelvic Intensity-Modulated Radiation Therapy With Concurrent Cisplatin-Based Chemotherapy of Cervical Cancer on the Vaginal Microbiome
title_full Influence of Pelvic Intensity-Modulated Radiation Therapy With Concurrent Cisplatin-Based Chemotherapy of Cervical Cancer on the Vaginal Microbiome
title_fullStr Influence of Pelvic Intensity-Modulated Radiation Therapy With Concurrent Cisplatin-Based Chemotherapy of Cervical Cancer on the Vaginal Microbiome
title_full_unstemmed Influence of Pelvic Intensity-Modulated Radiation Therapy With Concurrent Cisplatin-Based Chemotherapy of Cervical Cancer on the Vaginal Microbiome
title_short Influence of Pelvic Intensity-Modulated Radiation Therapy With Concurrent Cisplatin-Based Chemotherapy of Cervical Cancer on the Vaginal Microbiome
title_sort influence of pelvic intensity-modulated radiation therapy with concurrent cisplatin-based chemotherapy of cervical cancer on the vaginal microbiome
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940522/
https://www.ncbi.nlm.nih.gov/pubmed/33708628
http://dx.doi.org/10.3389/fonc.2021.615439
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