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Factors Influencing Participation in COVID-19 Clinical Trials: A Multi-National Study

In 2020, the World Health Organization has characterized COVID-19, a disease caused by infection with the SARS-CoV-2 virus, as a pandemic. Although a few vaccines and drugs have been approved to, respectively, prevent or treat the disease, several clinical trials are still ongoing to test new vaccin...

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Autores principales: Abdelhafiz, Ahmed Samir, Abd ElHafeez, Samar, Khalil, Mohammad Adnan, Shahrouri, Manal, Alosaimi, Bandar, Salem, Raneem O., Alorabi, Mohamed, Abdelgawad, Fatma, Ahram, Mamoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940528/
https://www.ncbi.nlm.nih.gov/pubmed/33708777
http://dx.doi.org/10.3389/fmed.2021.608959
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author Abdelhafiz, Ahmed Samir
Abd ElHafeez, Samar
Khalil, Mohammad Adnan
Shahrouri, Manal
Alosaimi, Bandar
Salem, Raneem O.
Alorabi, Mohamed
Abdelgawad, Fatma
Ahram, Mamoun
author_facet Abdelhafiz, Ahmed Samir
Abd ElHafeez, Samar
Khalil, Mohammad Adnan
Shahrouri, Manal
Alosaimi, Bandar
Salem, Raneem O.
Alorabi, Mohamed
Abdelgawad, Fatma
Ahram, Mamoun
author_sort Abdelhafiz, Ahmed Samir
collection PubMed
description In 2020, the World Health Organization has characterized COVID-19, a disease caused by infection with the SARS-CoV-2 virus, as a pandemic. Although a few vaccines and drugs have been approved to, respectively, prevent or treat the disease, several clinical trials are still ongoing to test new vaccines or drugs to mitigate the burden of the pandemic. Few studies have shown the role of host genetics in disease prognosis and drug response highlighting the importance of diverse participation in COVID-19 clinical trials. The goal of this study is to assess public attitudes in Egypt, Saudi Arabia, and Jordan toward participating in COVID-19 clinical trials and to identify the factors that may influence their attitude. An online questionnaire was developed and distributed among the target group through social media platforms. The number of responses was 1,576. Three quarters (74.9%) of participants heard about clinical trials before, 57.6% of them had a positive attitude toward participation in COVID-19 clinical trials. The conduct of clinical trials in accordance with the scientific, research, and ethical guidelines was a strong predictor of willingness to participate in clinical trials. Other positive factors also included protection of family from COVID-19 and contributing to the return to normal community life as well as receiving additional healthcare benefit was the fourth significant predictor. On the other hand, the thought that clinical trials can have a negative impact on the health of participants strongly predicted the unwillingness of individuals to participate in such trials. This was followed by having limited information about the novel coronavirus and COVID-19 and the lack of trust in physicians and hospitals. In general, Arab citizens are accepting the concept and have a positive attitude toward COVID-19 clinical trials. Increasing awareness of COVID-19 and clinical trials, enforcing the concept of altruism, and placing clear policies in conducting clinical trials are needed to increase participation in clinical trials among Arabs.
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spelling pubmed-79405282021-03-10 Factors Influencing Participation in COVID-19 Clinical Trials: A Multi-National Study Abdelhafiz, Ahmed Samir Abd ElHafeez, Samar Khalil, Mohammad Adnan Shahrouri, Manal Alosaimi, Bandar Salem, Raneem O. Alorabi, Mohamed Abdelgawad, Fatma Ahram, Mamoun Front Med (Lausanne) Medicine In 2020, the World Health Organization has characterized COVID-19, a disease caused by infection with the SARS-CoV-2 virus, as a pandemic. Although a few vaccines and drugs have been approved to, respectively, prevent or treat the disease, several clinical trials are still ongoing to test new vaccines or drugs to mitigate the burden of the pandemic. Few studies have shown the role of host genetics in disease prognosis and drug response highlighting the importance of diverse participation in COVID-19 clinical trials. The goal of this study is to assess public attitudes in Egypt, Saudi Arabia, and Jordan toward participating in COVID-19 clinical trials and to identify the factors that may influence their attitude. An online questionnaire was developed and distributed among the target group through social media platforms. The number of responses was 1,576. Three quarters (74.9%) of participants heard about clinical trials before, 57.6% of them had a positive attitude toward participation in COVID-19 clinical trials. The conduct of clinical trials in accordance with the scientific, research, and ethical guidelines was a strong predictor of willingness to participate in clinical trials. Other positive factors also included protection of family from COVID-19 and contributing to the return to normal community life as well as receiving additional healthcare benefit was the fourth significant predictor. On the other hand, the thought that clinical trials can have a negative impact on the health of participants strongly predicted the unwillingness of individuals to participate in such trials. This was followed by having limited information about the novel coronavirus and COVID-19 and the lack of trust in physicians and hospitals. In general, Arab citizens are accepting the concept and have a positive attitude toward COVID-19 clinical trials. Increasing awareness of COVID-19 and clinical trials, enforcing the concept of altruism, and placing clear policies in conducting clinical trials are needed to increase participation in clinical trials among Arabs. Frontiers Media S.A. 2021-02-23 /pmc/articles/PMC7940528/ /pubmed/33708777 http://dx.doi.org/10.3389/fmed.2021.608959 Text en Copyright © 2021 Abdelhafiz, Abd ElHafeez, Khalil, Shahrouri, Alosaimi, Salem, Alorabi, Abdelgawad and Ahram. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Abdelhafiz, Ahmed Samir
Abd ElHafeez, Samar
Khalil, Mohammad Adnan
Shahrouri, Manal
Alosaimi, Bandar
Salem, Raneem O.
Alorabi, Mohamed
Abdelgawad, Fatma
Ahram, Mamoun
Factors Influencing Participation in COVID-19 Clinical Trials: A Multi-National Study
title Factors Influencing Participation in COVID-19 Clinical Trials: A Multi-National Study
title_full Factors Influencing Participation in COVID-19 Clinical Trials: A Multi-National Study
title_fullStr Factors Influencing Participation in COVID-19 Clinical Trials: A Multi-National Study
title_full_unstemmed Factors Influencing Participation in COVID-19 Clinical Trials: A Multi-National Study
title_short Factors Influencing Participation in COVID-19 Clinical Trials: A Multi-National Study
title_sort factors influencing participation in covid-19 clinical trials: a multi-national study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940528/
https://www.ncbi.nlm.nih.gov/pubmed/33708777
http://dx.doi.org/10.3389/fmed.2021.608959
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