Cargando…

The mTORC1/eIF4E/HIF-1α Pathway Mediates Glycolysis to Support Brain Hypoxia Resistance in the Gansu Zokor, Eospalax cansus

The Gansu zokor (Eospalax cansus) is a subterranean rodent species that is unique to China. These creatures inhabit underground burrows with a hypoxia environment. Metabolic energy patterns in subterranean rodents have become a recent focus of research; however, little is known about brain energy me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Jinyan, Fan, Lele, Han, Yuming, Guo, Juanjuan, Hao, Zhiqiang, Cao, Lingna, Kang, Jiamin, Wang, Xiaoqin, He, Jianping, Li, Jingang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940537/ https://www.ncbi.nlm.nih.gov/pubmed/33708138 http://dx.doi.org/10.3389/fphys.2021.626240

Ejemplares similares

Gut Microbiome Alterations and Hepatic Metabolic Flexibility in the Gansu Zokor, Eospalax cansus: Adaptation to Hypoxic Niches
por: Lin, Jinyan, et al.
Publicado: (2022)

Microbial Biogeography along the Gastrointestinal Tract Segments of Sympatric Subterranean Rodents (Eospalax baileyi and Eospalax cansus)
por: Liu, Daoxin, et al.
Publicado: (2021)

The associations between intestinal bacteria of Eospalax cansus and soil bacteria of its habitat
por: Zou, Yao, et al.
Publicado: (2022)

Characteristics of the mitochondrial genome of Qinling zokor (Eospalax rufescens)
por: Song, Pengfei, et al.
Publicado: (2020)

Gut Microbiome Changes in Captive Plateau Zokors (Eospalax baileyi)
por: Liu, Daoxin, et al.
Publicado: (2021)

Seismic Signaling for Detection of Empty Tunnels in the Plateau Zokor, Eospalax baileyi
por: Dong, Kechi, et al.
Publicado: (2023)

Next generation sequencing yields the complete mitogenome of Smith’s zokor (Eospalax smithii)
por: Cai, Zhenyuan, et al.
Publicado: (2020)

Seasonal Expression of Gonadotropin Genes in the Pituitary and Testes of Male Plateau Zokor (Eospalax baileyi)
por: An, Kang, et al.
Publicado: (2022)

Genetic variation in bitter taste receptor genes influences the foraging behavior of plateau zokor (Eospalax baileyi)
por: Zhao, Fang, et al.
Publicado: (2016)

Molecular Characterization of a New Moniliformis sp. From a Plateau Zokor (Eospalax fontanierii baileyi) in China
por: Dai, Guo-Dong, et al.
Publicado: (2022)

Comparative phylogeography of the plateau zokor (Eospalax baileyi) and its host-associated flea (Neopsylla paranoma) in the Qinghai-Tibet Plateau
por: Lin, Gonghua, et al.
Publicado: (2014)

Comparative transcriptomes reveal geographic differences in the ability of the liver of plateau zokors (Eospalax baileyi) to respond and adapt to toxic plants
por: Tan, Yuchen, et al.
Publicado: (2023)

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding
por: Livingstone, Mark, et al.
Publicado: (2012)

Function‐related Drivers of Skull Morphometric Variation and Sexual Size Dimorphism in a Subterranean Rodent, Plateau Zokor (Eospalax baileyi)
por: Su, Junhu, et al.
Publicado: (2018)

Simulation of Soil Temperature under Plateau Zokor’s (Eospalax baileyi) Disturbance in the Qinghai Lake Watershed, Northeast Qinghai–Tibet Plateau
por: Xie, Ting, et al.
Publicado: (2023)

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
por: Gandin, Valentina, et al.
Publicado: (2016)

Identification and Functional Analysis of lncRNAs Responsive to Hypoxia in Eospalax fontanierii
por: Hao, Zhiqiang, et al.
Publicado: (2021)

Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress
por: Misra, Jagannath, et al.
Publicado: (2021)

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway
por: Joubert, Pierre-Emmanuel, et al.
Publicado: (2015)

Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α
por: Klann, Kevin, et al.
Publicado: (2020)

Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity
por: Crombie, Elisa M., et al.
Publicado: (2022)

Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs)
por: Rios-Fuller, Tiffany J., et al.
Publicado: (2020)

Transcriptome analysis of the liver of Eospalax fontanierii under hypoxia
por: Hao, Zhiqiang, et al.
Publicado: (2021)

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells
por: Eckerdt, Frank, et al.
Publicado: (2014)

The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
por: Yi, Woelsung, et al.
Publicado: (2017)

Phylogenetic relationships of the zokor genus Eospalax (Mammalia, Rodentia, Spalacidae) inferred from whole-genome analyses, with description of a new species endemic to Hengduan Mountains
por: Zhang, Tao, et al.
Publicado: (2022)

A Comparative Study on the Distribution Pattern of Endocrine Cells in the Gastrointestinal Tract of Two Small Alpine Mammals, Plateau Zokor (Eospalax baileyi) and Plateau Pika (Ochotona curzoniae)
por: Cai, Xincheng, et al.
Publicado: (2023)

Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
por: Wang, Zeng, et al.
Publicado: (2020)

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1
por: Morris, Christelle, et al.
Publicado: (2021)

Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway: Erratum
por: Wang, Zeng, et al.
Publicado: (2022)

mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells
por: Jossé, Lyne, et al.
Publicado: (2016)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

eIF4A inactivates TORC1 in response to amino acid starvation
por: Tsokanos, Foivos‐Filippos, et al.
Publicado: (2016)

mTORc1 activity is necessary and sufficient for phosphorylation of eNOS(S1177)
por: Decker, Brandee, et al.
Publicado: (2018)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Suppression of Hypoxia-Inducible Factor 1α (HIF-1α) by Tirapazamine Is Dependent on eIF2α Phosphorylation Rather Than the mTORC1/4E-BP1 Pathway
por: Zhang, Jun, et al.
Publicado: (2010)

E2F1 Regulates Cellular Growth by mTORC1 Signaling
por: Real, Sebastian, et al.
Publicado: (2011)

Synergistic activation of eIF4A by eIF4B and eIF4G
por: Nielsen, Klaus H., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_13vf08r00ni3okca7jm38bvm9u