Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers

Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. This protein–protein interaction represents an attractive target in cancer research and therapy. Here, we report a sophisticated strategy addressing Surv...

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Detalles Bibliográficos
Autores principales: Meiners, Annika, Bäcker, Sandra, Hadrović, Inesa, Heid, Christian, Beuck, Christine, Ruiz-Blanco, Yasser B., Mieres-Perez, Joel, Pörschke, Marius, Grad, Jean-Noël, Vallet, Cecilia, Hoffmann, Daniel, Bayer, Peter, Sánchez-García, Elsa, Schrader, Thomas, Knauer, Shirley K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940618/
https://www.ncbi.nlm.nih.gov/pubmed/33686072
http://dx.doi.org/10.1038/s41467-021-21753-9

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