Cargando…
Prioritizing non-coding regions based on human genomic constraint and sequence context with deep learning
Elucidating functionality in non-coding regions is a key challenge in human genomics. It has been shown that intolerance to variation of coding and proximal non-coding sequence is a strong predictor of human disease relevance. Here, we integrate intolerance to variation, functional genomic annotatio...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940646/ https://www.ncbi.nlm.nih.gov/pubmed/33686085 http://dx.doi.org/10.1038/s41467-021-21790-4 |