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The Role of Siglec-G on Immune Cells in Sepsis

Sepsis is a life-threatening clinical syndrome that results from an overwhelming immune response to infection. During sepsis, immune cells are activated by sensing pathogen-associated molecular patterns and damage-associated molecular patterns (DAMPs) through pattern recognizing receptors (PRRs). Re...

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Autores principales: Royster, William, Wang, Ping, Aziz, Monowar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940683/
https://www.ncbi.nlm.nih.gov/pubmed/33708213
http://dx.doi.org/10.3389/fimmu.2021.621627
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author Royster, William
Wang, Ping
Aziz, Monowar
author_facet Royster, William
Wang, Ping
Aziz, Monowar
author_sort Royster, William
collection PubMed
description Sepsis is a life-threatening clinical syndrome that results from an overwhelming immune response to infection. During sepsis, immune cells are activated by sensing pathogen-associated molecular patterns and damage-associated molecular patterns (DAMPs) through pattern recognizing receptors (PRRs). Regulation of the immune response is essential to preventing or managing sepsis. Sialic acid-binding immunoglobulin-type lectin-G (Siglec-G), a CD33 group of Siglec expressed in B-1a cells and other hematopoietic cells, plays an important immunoregulatory role. B-1a cells, a subtype of B lymphocytes, spontaneously produce natural IgM which confers protection against infection. B-1a cells also produce IL-10, GM-CSF, and IL-35 to control inflammation. Sialic acids are present on cell membranes, receptors, and glycoproteins. Siglec-G binds to the sialic acid residues on the B cell receptor (BCR) and controls BCR-mediated signal transduction, thereby maintaining homeostasis of Ca(++) influx and NFATc1 expression. Siglec-G inhibits NF-κB activation in B-1a cells and regulates B-1a cell proliferation. In myeloid cells, Siglec-G inhibits DAMP-mediated inflammation by forming a ternary complex with DAMP and CD24. Thus, preserving Siglec-G’s function could be a novel therapeutic approach in sepsis. Here, we review the immunoregulatory functions of Siglec-G in B-1a cells and myeloid cells in sepsis. A clear understanding of Siglec-G is important to developing novel therapeutics in treating sepsis.
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spelling pubmed-79406832021-03-10 The Role of Siglec-G on Immune Cells in Sepsis Royster, William Wang, Ping Aziz, Monowar Front Immunol Immunology Sepsis is a life-threatening clinical syndrome that results from an overwhelming immune response to infection. During sepsis, immune cells are activated by sensing pathogen-associated molecular patterns and damage-associated molecular patterns (DAMPs) through pattern recognizing receptors (PRRs). Regulation of the immune response is essential to preventing or managing sepsis. Sialic acid-binding immunoglobulin-type lectin-G (Siglec-G), a CD33 group of Siglec expressed in B-1a cells and other hematopoietic cells, plays an important immunoregulatory role. B-1a cells, a subtype of B lymphocytes, spontaneously produce natural IgM which confers protection against infection. B-1a cells also produce IL-10, GM-CSF, and IL-35 to control inflammation. Sialic acids are present on cell membranes, receptors, and glycoproteins. Siglec-G binds to the sialic acid residues on the B cell receptor (BCR) and controls BCR-mediated signal transduction, thereby maintaining homeostasis of Ca(++) influx and NFATc1 expression. Siglec-G inhibits NF-κB activation in B-1a cells and regulates B-1a cell proliferation. In myeloid cells, Siglec-G inhibits DAMP-mediated inflammation by forming a ternary complex with DAMP and CD24. Thus, preserving Siglec-G’s function could be a novel therapeutic approach in sepsis. Here, we review the immunoregulatory functions of Siglec-G in B-1a cells and myeloid cells in sepsis. A clear understanding of Siglec-G is important to developing novel therapeutics in treating sepsis. Frontiers Media S.A. 2021-02-23 /pmc/articles/PMC7940683/ /pubmed/33708213 http://dx.doi.org/10.3389/fimmu.2021.621627 Text en Copyright © 2021 Royster, Wang and Aziz http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Royster, William
Wang, Ping
Aziz, Monowar
The Role of Siglec-G on Immune Cells in Sepsis
title The Role of Siglec-G on Immune Cells in Sepsis
title_full The Role of Siglec-G on Immune Cells in Sepsis
title_fullStr The Role of Siglec-G on Immune Cells in Sepsis
title_full_unstemmed The Role of Siglec-G on Immune Cells in Sepsis
title_short The Role of Siglec-G on Immune Cells in Sepsis
title_sort role of siglec-g on immune cells in sepsis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940683/
https://www.ncbi.nlm.nih.gov/pubmed/33708213
http://dx.doi.org/10.3389/fimmu.2021.621627
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