Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies

The optimization of upstream and downstream processes for production of recombinant adeno-associated virus (rAAV) with consistent quality depends on the ability to rapidly characterize critical quality attributes (CQAs). In the context of rAAV production, the virus titer, capsid content, and aggrega...

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Detalles Bibliográficos
Autores principales: Gimpel, Andreas L., Katsikis, Georgios, Sha, Sha, Maloney, Andrew John, Hong, Moo Sun, Nguyen, Tam N.T., Wolfrum, Jacqueline, Springs, Stacy L., Sinskey, Anthony J., Manalis, Scott R., Barone, Paul W., Braatz, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940698/
https://www.ncbi.nlm.nih.gov/pubmed/33738328
http://dx.doi.org/10.1016/j.omtm.2021.02.010

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