A more efficient CRISPR-Cas12a variant derived from Lachnospiraceae bacterium MA2020

CRISPR effector proteins introduce double-stranded breaks into the mammalian genome, facilitating gene editing by non-homologous end-joining or homology-directed repair. Unlike the more commonly studied Cas9, the CRISPR effector protein Cas12a/Cpf1 recognizes a T-rich protospacer adjacent motif (PAM...

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Detalles Bibliográficos
Autores principales: Tran, Mai H., Park, Hajeung, Nobles, Christopher L., Karunadharma, Pabalu, Pan, Li, Zhong, Guocai, Wang, Haimin, He, Wenhui, Ou, Tianling, Crynen, Gogce, Sheptack, Kelly, Stiskin, Ian, Mou, Huihui, Farzan, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940699/
https://www.ncbi.nlm.nih.gov/pubmed/33738137
http://dx.doi.org/10.1016/j.omtn.2021.02.012

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