CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology

Inducible conditional knockout mice are important tools for studying gene function and disease therapy, but their generation is costly and time-consuming. We introduced clustered regularly interspaced short palindromic repeats (CRISPR) and Cre into an LSL-Cas9 transgene-carrying mouse line by using...

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Detalles Bibliográficos
Autores principales: Xiao, Dan, Zhang, Weifeng, Wang, Qing, Li, Xing, Zhang, Yuan, Rasouli, Javad, Casella, Giacomo, Ciric, Bogoljub, Curtis, Mark, Rostami, Abdolmohamad, Zhang, Guang-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940702/
https://www.ncbi.nlm.nih.gov/pubmed/33738329
http://dx.doi.org/10.1016/j.omtm.2021.02.012

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