The Reality of Randomized Controlled Trials for Assessing the Benefit of Proton Therapy: Critically Examining the Intent-to-Treat Principle in the Presence of Insurance Denial

PURPOSE: This study hypothesized that insurance denial would lead to bias and loss of statistical power when evaluating the results from an intent-to-treat (ITT), per-protocol, and as-treated analyses using a simulated randomized clinical trial comparing proton therapy to intensity modulated radiati...

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Detalles Bibliográficos
Autores principales: Hernandez, Mike, Lee, J. Jack, Yeap, Beow Y., Ye, Rong, Foote, Robert L., Busse, Paul, Patel, Samir H., Dagan, Roi, Snider, James, Mohammed, Nasiruddin, Lin, Alexander, Blanchard, Pierre, Cantor, Scott B., Teferra, Menna Y., Hutcheson, Kate, Yepes, Pablo, Mohan, Radhe, Liao, Zhongxing, DeLaney, Thomas F., Frank, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Critical Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940795/
https://www.ncbi.nlm.nih.gov/pubmed/33732960
http://dx.doi.org/10.1016/j.adro.2020.100635

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