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Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases

Chemical modifications have been extensively used for therapeutic oligonucleotides because they strongly enhance the stability against nucleases, binding affinity to the targets, and efficacy. We previously reported that oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[...

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Detalles Bibliográficos
Autores principales:	Horie, Naohiro, Yamaguchi, Takao, Kumagai, Shinji, Obika, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2021
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940814/ https://www.ncbi.nlm.nih.gov/pubmed/33747234 http://dx.doi.org/10.3762/bjoc.17.54

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