Nuclear Factor Erythroid 2-Related Factor 2 Activation Might Mitigate Clinical Symptoms in Friedreich’s Ataxia: Clues of an “Out-Brain Origin” of the Disease From a Family Study

Friedreich’s ataxia (FRDA) is the most frequent autosomal recessive ataxia in western countries, with a mean age of onset at 10–15 years. Patients manifest progressive cerebellar and sensory ataxia, dysarthria, lower limb pyramidal weakness, and other systemic manifestations. Previously, we describe...

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Detalles Bibliográficos
Autores principales: Petrillo, Sara, Santoro, Massimo, La Rosa, Piergiorgio, Perna, Alessia, Gallo, Maria Giovanna, Bertini, Enrico Silvio, Silvestri, Gabriella, Piemonte, Fiorella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940825/
https://www.ncbi.nlm.nih.gov/pubmed/33708070
http://dx.doi.org/10.3389/fnins.2021.638810

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