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The usefulness of intraoperative consultation for the diagnosis of borderline ovarian tumors

BACKGROUND: Borderline ovarian tumors (BTs) must be recognized during the surgery by intraoperative consultation (IOC) to guide surgical treatment; however, this diagnosis can be imprecise. Therefore, this study aimed to evaluate the diagnostic accuracy of IOC for the diagnosis of BT. METHODS: A ret...

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Autores principales: Salcedo-Hernández, Rosa A., Cantú-de-León, David F., Pérez-Montiel, Delia, García-Pérez, Leticia, Lino-Silva, Leonardo S., Zepeda-Najar, César, Barquet-Muñoz, Salim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940902/
https://www.ncbi.nlm.nih.gov/pubmed/33708888
http://dx.doi.org/10.21037/atm-20-3932
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author Salcedo-Hernández, Rosa A.
Cantú-de-León, David F.
Pérez-Montiel, Delia
García-Pérez, Leticia
Lino-Silva, Leonardo S.
Zepeda-Najar, César
Barquet-Muñoz, Salim A.
author_facet Salcedo-Hernández, Rosa A.
Cantú-de-León, David F.
Pérez-Montiel, Delia
García-Pérez, Leticia
Lino-Silva, Leonardo S.
Zepeda-Najar, César
Barquet-Muñoz, Salim A.
author_sort Salcedo-Hernández, Rosa A.
collection PubMed
description BACKGROUND: Borderline ovarian tumors (BTs) must be recognized during the surgery by intraoperative consultation (IOC) to guide surgical treatment; however, this diagnosis can be imprecise. Therefore, this study aimed to evaluate the diagnostic accuracy of IOC for the diagnosis of BT. METHODS: A retrospective cohort study was carried out including all women diagnosed with a pelvic tumor consecutively surgically treated from 2005 to 2015 with IOC. We calculated the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and likelihood ratios (LR) for the IOC and BTs. RESULTS: A total of 758 patients were enrolled, the median age was 44 years, the median tumor size was 11.8 cm, and the median CA-125 levels were 45.65 U/µL. After IOC, 458 (64.1%) cases were diagnosed as benign, 111 (14.7%) as BT, and 161 (21.2%) as malignant. The definitive diagnosis was a benign tumor in 448 (59.1%) cases, BT in 110 (14.5%), and 200 (26.4%) cases were malignant. The diagnostic accuracy of the IOC for BT diagnosis was 89.8% (sensitivity =65.5%, specificity =93.9%). The diagnosis performance of IOC for the diagnosis between BT and benign tumors (n=546) had a sensitivity of 69.9%, a specificity of 98.4%, and a diagnostic accuracy of 84%; meanwhile for the diagnosis between BT and malignant tumors (n=242) IOC had a sensitivity of 92.3%, a specificity of 81.7%, and a diagnostic accuracy of 87%. CONCLUSIONS: For practitioners, knowing the accuracy and limitations of the IOC for BT enables the better selection of cases to perform a complete staging surgery.
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spelling pubmed-79409022021-03-10 The usefulness of intraoperative consultation for the diagnosis of borderline ovarian tumors Salcedo-Hernández, Rosa A. Cantú-de-León, David F. Pérez-Montiel, Delia García-Pérez, Leticia Lino-Silva, Leonardo S. Zepeda-Najar, César Barquet-Muñoz, Salim A. Ann Transl Med Original Article BACKGROUND: Borderline ovarian tumors (BTs) must be recognized during the surgery by intraoperative consultation (IOC) to guide surgical treatment; however, this diagnosis can be imprecise. Therefore, this study aimed to evaluate the diagnostic accuracy of IOC for the diagnosis of BT. METHODS: A retrospective cohort study was carried out including all women diagnosed with a pelvic tumor consecutively surgically treated from 2005 to 2015 with IOC. We calculated the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and likelihood ratios (LR) for the IOC and BTs. RESULTS: A total of 758 patients were enrolled, the median age was 44 years, the median tumor size was 11.8 cm, and the median CA-125 levels were 45.65 U/µL. After IOC, 458 (64.1%) cases were diagnosed as benign, 111 (14.7%) as BT, and 161 (21.2%) as malignant. The definitive diagnosis was a benign tumor in 448 (59.1%) cases, BT in 110 (14.5%), and 200 (26.4%) cases were malignant. The diagnostic accuracy of the IOC for BT diagnosis was 89.8% (sensitivity =65.5%, specificity =93.9%). The diagnosis performance of IOC for the diagnosis between BT and benign tumors (n=546) had a sensitivity of 69.9%, a specificity of 98.4%, and a diagnostic accuracy of 84%; meanwhile for the diagnosis between BT and malignant tumors (n=242) IOC had a sensitivity of 92.3%, a specificity of 81.7%, and a diagnostic accuracy of 87%. CONCLUSIONS: For practitioners, knowing the accuracy and limitations of the IOC for BT enables the better selection of cases to perform a complete staging surgery. AME Publishing Company 2021-02 /pmc/articles/PMC7940902/ /pubmed/33708888 http://dx.doi.org/10.21037/atm-20-3932 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Salcedo-Hernández, Rosa A.
Cantú-de-León, David F.
Pérez-Montiel, Delia
García-Pérez, Leticia
Lino-Silva, Leonardo S.
Zepeda-Najar, César
Barquet-Muñoz, Salim A.
The usefulness of intraoperative consultation for the diagnosis of borderline ovarian tumors
title The usefulness of intraoperative consultation for the diagnosis of borderline ovarian tumors
title_full The usefulness of intraoperative consultation for the diagnosis of borderline ovarian tumors
title_fullStr The usefulness of intraoperative consultation for the diagnosis of borderline ovarian tumors
title_full_unstemmed The usefulness of intraoperative consultation for the diagnosis of borderline ovarian tumors
title_short The usefulness of intraoperative consultation for the diagnosis of borderline ovarian tumors
title_sort usefulness of intraoperative consultation for the diagnosis of borderline ovarian tumors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940902/
https://www.ncbi.nlm.nih.gov/pubmed/33708888
http://dx.doi.org/10.21037/atm-20-3932
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