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Metabolically healthy obesity and risk of stroke: a meta-analysis of prospective cohort studies

BACKGROUND: Metabolic healthy obesity (MHO) is a unique subgroup of overweight and obese individuals with normal metabolic characteristics. Its association with the risk of stroke remains unclear. We aimed to examine the risk of stroke in MHO individuals and the further associations between stroke a...

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Autores principales: Ma, Ling-Zhi, Sun, Fu-Rong, Wang, Zuo-Teng, Tan, Lin, Hou, Xiao-He, Ou, Ya-Nan, Dong, Qiang, Yu, Jin-Tai, Tan, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940916/
https://www.ncbi.nlm.nih.gov/pubmed/33708824
http://dx.doi.org/10.21037/atm-20-4387
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author Ma, Ling-Zhi
Sun, Fu-Rong
Wang, Zuo-Teng
Tan, Lin
Hou, Xiao-He
Ou, Ya-Nan
Dong, Qiang
Yu, Jin-Tai
Tan, Lan
author_facet Ma, Ling-Zhi
Sun, Fu-Rong
Wang, Zuo-Teng
Tan, Lin
Hou, Xiao-He
Ou, Ya-Nan
Dong, Qiang
Yu, Jin-Tai
Tan, Lan
author_sort Ma, Ling-Zhi
collection PubMed
description BACKGROUND: Metabolic healthy obesity (MHO) is a unique subgroup of overweight and obese individuals with normal metabolic characteristics. Its association with the risk of stroke remains unclear. We aimed to examine the risk of stroke in MHO individuals and the further associations between stroke and metabolic abnormalities under different bodyweight conditions. METHODS: We systematically searched PubMed, Embase and Cochrane Library from December 1946 to January 2019, and only included prospective cohort studies. Random effects models were used to evaluate the pooled risk ratios (RR) and 95% confidence intervals (95% CI) of incident stroke. RESULTS: A total of eight studies comprising 4,256,888 participants were included in the meta-analysis. MHO individuals had an increased risk of stroke compared with metabolically healthy normal weight (MH-NW) individuals (RR =1.17, 95% CI: 1.11–1.23). However, the stroke risk of metabolically healthy overweight individuals was the same (RR =1.02, 95% CI: 0.84–1.23). All groups with unhealthy metabolism had a similarly elevated risk: normal weight (RR =1.83, 95% CI: 1.57–2.14), overweight (RR =1.93, 95% CI: 1.44–2.58), and obesity (RR =2.00, 95% CI: 1.40–2.87). CONCLUSIONS: The meta-analysis confirms a positive association between MHO phenotype and the risk of stroke. Individuals with metabolic abnormalities under different bodyweight conditions are at elevated risk.
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spelling pubmed-79409162021-03-10 Metabolically healthy obesity and risk of stroke: a meta-analysis of prospective cohort studies Ma, Ling-Zhi Sun, Fu-Rong Wang, Zuo-Teng Tan, Lin Hou, Xiao-He Ou, Ya-Nan Dong, Qiang Yu, Jin-Tai Tan, Lan Ann Transl Med Original Article BACKGROUND: Metabolic healthy obesity (MHO) is a unique subgroup of overweight and obese individuals with normal metabolic characteristics. Its association with the risk of stroke remains unclear. We aimed to examine the risk of stroke in MHO individuals and the further associations between stroke and metabolic abnormalities under different bodyweight conditions. METHODS: We systematically searched PubMed, Embase and Cochrane Library from December 1946 to January 2019, and only included prospective cohort studies. Random effects models were used to evaluate the pooled risk ratios (RR) and 95% confidence intervals (95% CI) of incident stroke. RESULTS: A total of eight studies comprising 4,256,888 participants were included in the meta-analysis. MHO individuals had an increased risk of stroke compared with metabolically healthy normal weight (MH-NW) individuals (RR =1.17, 95% CI: 1.11–1.23). However, the stroke risk of metabolically healthy overweight individuals was the same (RR =1.02, 95% CI: 0.84–1.23). All groups with unhealthy metabolism had a similarly elevated risk: normal weight (RR =1.83, 95% CI: 1.57–2.14), overweight (RR =1.93, 95% CI: 1.44–2.58), and obesity (RR =2.00, 95% CI: 1.40–2.87). CONCLUSIONS: The meta-analysis confirms a positive association between MHO phenotype and the risk of stroke. Individuals with metabolic abnormalities under different bodyweight conditions are at elevated risk. AME Publishing Company 2021-02 /pmc/articles/PMC7940916/ /pubmed/33708824 http://dx.doi.org/10.21037/atm-20-4387 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Ma, Ling-Zhi
Sun, Fu-Rong
Wang, Zuo-Teng
Tan, Lin
Hou, Xiao-He
Ou, Ya-Nan
Dong, Qiang
Yu, Jin-Tai
Tan, Lan
Metabolically healthy obesity and risk of stroke: a meta-analysis of prospective cohort studies
title Metabolically healthy obesity and risk of stroke: a meta-analysis of prospective cohort studies
title_full Metabolically healthy obesity and risk of stroke: a meta-analysis of prospective cohort studies
title_fullStr Metabolically healthy obesity and risk of stroke: a meta-analysis of prospective cohort studies
title_full_unstemmed Metabolically healthy obesity and risk of stroke: a meta-analysis of prospective cohort studies
title_short Metabolically healthy obesity and risk of stroke: a meta-analysis of prospective cohort studies
title_sort metabolically healthy obesity and risk of stroke: a meta-analysis of prospective cohort studies
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940916/
https://www.ncbi.nlm.nih.gov/pubmed/33708824
http://dx.doi.org/10.21037/atm-20-4387
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