Surgical outcome of a female patient with comorbid epilepsy and psychogenic non-epileptic seizures confirmed with video-EEG monitoring

Despite common comorbidities of epileptic seizure (ES) and psychogenic nonepileptic seizure (PNES), reports regarding the clinical management of the two coexisting disorders have traditionally only focused on non-surgical approaches such as medication and psychotherapy. Epileptogenic zonectomy following comprehensive presurgical evaluation could lead to seizure control and even seizure free in refractory epilepsy patients. However, its effect on PNES which is of clinical significance remains to be explored. Here, we present a favorable surgical outcome in a middle-aged woman with refractory epilepsy with concomitant video-electroencephalograph-confirmed PNES. The patient has been ES free post right-sided anterior temporal lobectomy with unchanged antiepileptic medication. Meanwhile, remarkable improvement of her PNES has been reported although she did not undergo psychiatric or psychological therapy following surgery. The treatment success achieved in this case suggests that comorbid PNES should not deprive patients with intractable epilepsy patients a chance to undergo surgical intervention if their epileptogenic zones could be identified during presurgical evaluation. Some patients could obtain relieves of both ES and PNES from appropriately performed epilepsy surgery. Nevertheless, the mechanisms underlying the findings in this report are still unknown. Further study is needed to investigate whether epileptogenic zonectomy itself or the patient’s positive mood brought by ES control contributes to postoperative alleviation of PNES.