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Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study

BACKGROUND: The objective of this study was to determine the causal relationship between habitual alcohol consumption with meals and lung cancer. METHODS: Public genetic summary data from two large consortia [the Neale Lab and the International Lung Cancer Consortium (ILCCO)] were used for analysis....

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Autores principales: Chen, Chongxiang, Hu, Qiaozhen, Wang, Jiaojiao, Wen, Tianmeng, Zhu, Chaoyang, Tan, Weiyan, Chen, Xuelin, Zhao, Qingyu, Wang, Wei, Cao, Huijiao, Li, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940946/
https://www.ncbi.nlm.nih.gov/pubmed/33708890
http://dx.doi.org/10.21037/atm-20-3063
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author Chen, Chongxiang
Hu, Qiaozhen
Wang, Jiaojiao
Wen, Tianmeng
Zhu, Chaoyang
Tan, Weiyan
Chen, Xuelin
Zhao, Qingyu
Wang, Wei
Cao, Huijiao
Li, Huan
author_facet Chen, Chongxiang
Hu, Qiaozhen
Wang, Jiaojiao
Wen, Tianmeng
Zhu, Chaoyang
Tan, Weiyan
Chen, Xuelin
Zhao, Qingyu
Wang, Wei
Cao, Huijiao
Li, Huan
author_sort Chen, Chongxiang
collection PubMed
description BACKGROUND: The objective of this study was to determine the causal relationship between habitual alcohol consumption with meals and lung cancer. METHODS: Public genetic summary data from two large consortia [the Neale Lab and the International Lung Cancer Consortium (ILCCO)] were used for analysis. As the instrumental variables of habitual alcohol consumption with meals, data on genetic variants were retrieved from Neale Lab. Additionally, genetic data from other consortia [Global Lipid Genetics Consortium (GLGC), Tobacco, Alcohol and Genetics (TAG), Genetic Investigation of Anthropocentric Traits (GIANT)] were utilized to determine whether alcohol could causally alter some general risk factors for lung cancer. The primary outcome was the risk of lung cancer (11,348 cases and 15,861 controls in the ILCCO). The R package TwoSampleMR was used for analysis. RESULTS: Based on the inverse variance weighted method, the results of the two-sample Mendelian randomization (MR) analyses indicated that commonly consuming alcohol with meals was a protective factor, reducing lung cancer risk [odds ratio (OR) 0.175, 95% confidence interval (CI): 0.045–0.682, P=0.012]. The heterogeneity analysis revealed that the causal relationship analyses of different types of lung cancer all had low heterogeneity (P>0.05). The horizontal pleiotropic study showed that major bias was unlikely. The MR assumptions did not seem to be violated. The causal relationship analyses between habitual alcohol consumption with meals and some risk factors for cancers showed that this alcohol consumption habit was a beneficial factor for reducing body mass index (BMI) and the number of cigarettes smoked per day. CONCLUSIONS: Habitual appropriate alcohol consumption with meals is a protective factor for the development of lung cancer.
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spelling pubmed-79409462021-03-10 Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study Chen, Chongxiang Hu, Qiaozhen Wang, Jiaojiao Wen, Tianmeng Zhu, Chaoyang Tan, Weiyan Chen, Xuelin Zhao, Qingyu Wang, Wei Cao, Huijiao Li, Huan Ann Transl Med Original Article BACKGROUND: The objective of this study was to determine the causal relationship between habitual alcohol consumption with meals and lung cancer. METHODS: Public genetic summary data from two large consortia [the Neale Lab and the International Lung Cancer Consortium (ILCCO)] were used for analysis. As the instrumental variables of habitual alcohol consumption with meals, data on genetic variants were retrieved from Neale Lab. Additionally, genetic data from other consortia [Global Lipid Genetics Consortium (GLGC), Tobacco, Alcohol and Genetics (TAG), Genetic Investigation of Anthropocentric Traits (GIANT)] were utilized to determine whether alcohol could causally alter some general risk factors for lung cancer. The primary outcome was the risk of lung cancer (11,348 cases and 15,861 controls in the ILCCO). The R package TwoSampleMR was used for analysis. RESULTS: Based on the inverse variance weighted method, the results of the two-sample Mendelian randomization (MR) analyses indicated that commonly consuming alcohol with meals was a protective factor, reducing lung cancer risk [odds ratio (OR) 0.175, 95% confidence interval (CI): 0.045–0.682, P=0.012]. The heterogeneity analysis revealed that the causal relationship analyses of different types of lung cancer all had low heterogeneity (P>0.05). The horizontal pleiotropic study showed that major bias was unlikely. The MR assumptions did not seem to be violated. The causal relationship analyses between habitual alcohol consumption with meals and some risk factors for cancers showed that this alcohol consumption habit was a beneficial factor for reducing body mass index (BMI) and the number of cigarettes smoked per day. CONCLUSIONS: Habitual appropriate alcohol consumption with meals is a protective factor for the development of lung cancer. AME Publishing Company 2021-02 /pmc/articles/PMC7940946/ /pubmed/33708890 http://dx.doi.org/10.21037/atm-20-3063 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Chen, Chongxiang
Hu, Qiaozhen
Wang, Jiaojiao
Wen, Tianmeng
Zhu, Chaoyang
Tan, Weiyan
Chen, Xuelin
Zhao, Qingyu
Wang, Wei
Cao, Huijiao
Li, Huan
Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study
title Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study
title_full Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study
title_fullStr Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study
title_full_unstemmed Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study
title_short Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study
title_sort habitual consumption of alcohol with meals and lung cancer: a mendelian randomization study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940946/
https://www.ncbi.nlm.nih.gov/pubmed/33708890
http://dx.doi.org/10.21037/atm-20-3063
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