Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine

Morphine is commonly used to relieve moderate to severe pain, but repeated doses cause opioid tolerance. Here, we used ATP sensor and fiber photometry to detect prefrontal ATP level. It showed that prefrontal ATP level decreased after morphine injection and the event amplitude tended to decrease wit...

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Detalles Bibliográficos
Autores principales: Zeng, Yeting, Luo, Huoqing, Gao, Zilong, Zhu, Xiaona, Shen, Yinbo, Li, Yulong, Hu, Ji, Yang, Jiajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940985/
https://www.ncbi.nlm.nih.gov/pubmed/33733073
http://dx.doi.org/10.1016/j.isci.2021.102213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940985/
https://www.ncbi.nlm.nih.gov/pubmed/33733073
http://dx.doi.org/10.1016/j.isci.2021.102213

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