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Computationally-guided design and affinity improvement of a protein binder targeting a specific site on HER2

A protein binder with a desired epitope and binding affinity is critical to the development of therapeutic agents. Here we present computationally-guided design and affinity improvement of a protein binder recognizing a specific site on domain IV of human epidermal growth factor receptor 2 (HER2). A...

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Detalles Bibliográficos
Autores principales:	Kim, Tae Yoon, Cha, Jeong Seok, Kim, Hoyoung, Choi, Yoonjoo, Cho, Hyun-Soo, Kim, Hak-Sung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941009/ https://www.ncbi.nlm.nih.gov/pubmed/33738081 http://dx.doi.org/10.1016/j.csbj.2021.02.013

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