An efficient and versatile CRISPR-Cas9 system for genetic manipulation of multi-drug resistant Klebsiella pneumoniae

Multi-drug resistant (MDR) Klebsiella pneumoniae remains an urgent public health threat. While whole-genome sequencing has helped identify genetic changes underlying resistance, functional validation remains difficult due to a lack of genetic manipulation systems for MDR K. pneumoniae. CRISPR-Cas9 h...

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Detalles Bibliográficos
Autores principales: McConville, Thomas H., Giddins, Marla J., Uhlemann, Anne-Catrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941085/
https://www.ncbi.nlm.nih.gov/pubmed/33733242
http://dx.doi.org/10.1016/j.xpro.2021.100373

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