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Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy
Colorectal cancer (CRC) is one of the most common malignant tumors, with the second-highest mortality of all 36 cancers worldwide. The roles of fatty acid metabolism in CRC were investigated to explore potential therapeutic strategies. The data files were downloaded from The Cancer Genome Atlas (TCG...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941088/ https://www.ncbi.nlm.nih.gov/pubmed/33738339 http://dx.doi.org/10.1016/j.omto.2021.02.010 |
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author | Ding, Chengsheng Shan, Zezhi Li, Mengcheng Chen, Hongqi Li, Xinxiang Jin, Zhiming |
author_facet | Ding, Chengsheng Shan, Zezhi Li, Mengcheng Chen, Hongqi Li, Xinxiang Jin, Zhiming |
author_sort | Ding, Chengsheng |
collection | PubMed |
description | Colorectal cancer (CRC) is one of the most common malignant tumors, with the second-highest mortality of all 36 cancers worldwide. The roles of fatty acid metabolism in CRC were investigated to explore potential therapeutic strategies. The data files were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Univariate and least absolute shrinkage and selection operator (LASSO) Cox regression analyses were used to construct a prognostic risk score model with fatty acid metabolism-related genes for predicting prognosis in CRC. Patients with a high-risk score had a poorer prognosis in TCGA cohort than those with a low-risk score and were confirmed in the GEO cohort. Further analysis using the “pRRophetic” R package revealed that low-risk patients were more sensitive to 5-fluorouracil. A comprehensive evaluation of the association between prognostic risk score model and tumor microenvironment (TME) characteristics showed that high-risk patients were suitable for activating a type I/II interferon (IFN) response and inflammation-promoting function. Tumor Immune Dysfunction and Exclusion (TIDE) and SubMap algorithm results also demonstrated that high-risk patients are more suitable for anti-CTLA4 immunotherapy. Therefore, the evaluation of the fatty acid metabolism pattern promotes our comprehension of TME infiltration characteristics, thus guiding effective immunotherapy regimens. |
format | Online Article Text |
id | pubmed-7941088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Society of Gene & Cell Therapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-79410882021-03-17 Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy Ding, Chengsheng Shan, Zezhi Li, Mengcheng Chen, Hongqi Li, Xinxiang Jin, Zhiming Mol Ther Oncolytics Original Article Colorectal cancer (CRC) is one of the most common malignant tumors, with the second-highest mortality of all 36 cancers worldwide. The roles of fatty acid metabolism in CRC were investigated to explore potential therapeutic strategies. The data files were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Univariate and least absolute shrinkage and selection operator (LASSO) Cox regression analyses were used to construct a prognostic risk score model with fatty acid metabolism-related genes for predicting prognosis in CRC. Patients with a high-risk score had a poorer prognosis in TCGA cohort than those with a low-risk score and were confirmed in the GEO cohort. Further analysis using the “pRRophetic” R package revealed that low-risk patients were more sensitive to 5-fluorouracil. A comprehensive evaluation of the association between prognostic risk score model and tumor microenvironment (TME) characteristics showed that high-risk patients were suitable for activating a type I/II interferon (IFN) response and inflammation-promoting function. Tumor Immune Dysfunction and Exclusion (TIDE) and SubMap algorithm results also demonstrated that high-risk patients are more suitable for anti-CTLA4 immunotherapy. Therefore, the evaluation of the fatty acid metabolism pattern promotes our comprehension of TME infiltration characteristics, thus guiding effective immunotherapy regimens. American Society of Gene & Cell Therapy 2021-02-18 /pmc/articles/PMC7941088/ /pubmed/33738339 http://dx.doi.org/10.1016/j.omto.2021.02.010 Text en © 2021. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Ding, Chengsheng Shan, Zezhi Li, Mengcheng Chen, Hongqi Li, Xinxiang Jin, Zhiming Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy |
title | Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy |
title_full | Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy |
title_fullStr | Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy |
title_full_unstemmed | Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy |
title_short | Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy |
title_sort | characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941088/ https://www.ncbi.nlm.nih.gov/pubmed/33738339 http://dx.doi.org/10.1016/j.omto.2021.02.010 |
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