Ultrapotent miniproteins targeting the receptor-binding domain protect against SARS-CoV-2 infection and disease in mice

Despite the introduction of public health measures and spike protein-based vaccines to mitigate the COVID-19 pandemic, SARS-CoV-2 infections and deaths continue to rise. Previously, we used a structural design approach to develop picomolar range miniproteins targeting the SARS-CoV-2 receptor binding...

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Detalles Bibliográficos
Autores principales: Case, James Brett, Chen, Rita E., Cao, Longxing, Ying, Baoling, Winkler, Emma S., Goreshnik, Inna, Shrihari, Swathi, Kafai, Natasha M., Bailey, Adam L., Xie, Xuping, Shi, Pei-Yong, Ravichandran, Rashmi, Carter, Lauren, Stewart, Lance, Baker, David, Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941621/
https://www.ncbi.nlm.nih.gov/pubmed/33688650
http://dx.doi.org/10.1101/2021.03.01.433110

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