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Muscle Strength Explains the Protective Effect of Physical Activity against COVID-19 Hospitalization among Adults aged 50 Years and Older

OBJECTIVES. Physical activity has been proposed as a protective factor for COVID-19 hospitalization. However, the mechanisms underlying this association are unclear. Here, we examined the association between physical activity and COVID-19 hospitalization and whether this relationship was explained b...

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Autores principales: Maltagliati, Silvio, Sieber, Stephen, Sarrazin, Philippe, Cullati, Stéphane, Chalabaev, Aïna, Millet, Grégoire P., Boisgontier, Matthieu P., Cheval, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941660/
https://www.ncbi.nlm.nih.gov/pubmed/33688683
http://dx.doi.org/10.1101/2021.02.25.21252451
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author Maltagliati, Silvio
Sieber, Stephen
Sarrazin, Philippe
Cullati, Stéphane
Chalabaev, Aïna
Millet, Grégoire P.
Boisgontier, Matthieu P.
Cheval, Boris
author_facet Maltagliati, Silvio
Sieber, Stephen
Sarrazin, Philippe
Cullati, Stéphane
Chalabaev, Aïna
Millet, Grégoire P.
Boisgontier, Matthieu P.
Cheval, Boris
author_sort Maltagliati, Silvio
collection PubMed
description OBJECTIVES. Physical activity has been proposed as a protective factor for COVID-19 hospitalization. However, the mechanisms underlying this association are unclear. Here, we examined the association between physical activity and COVID-19 hospitalization and whether this relationship was explained by other risk factors for severe COVID-19. METHOD. We used data from adults aged 50 years and older from the Survey of Health, Ageing and Retirement in Europe. The outcome was self-reported hospitalization due to COVID-19 measured before August 2020. The main exposure was usual physical activity, self-reported between 2004 and 2017. Data were analyzed using logistic regression models. RESULTS. Among the 3139 participants included in the study (69.3 ± 8.5 years, 1763 women), 266 were tested positive for COVID-19 and 66 were hospitalized. Results showed that individuals who engaged in physical activity more than once a week had lower odds of COVID-19 hospitalization than individuals who hardly ever or never engaged in physical activity (odds ratios = 0.41, 95% confidence interval = 0.22–0.74, p = .004). This association between physical activity and COVID-19 hospitalization was explained by muscle strength, but not by other risk factors. CONCLUSION. These findings suggest that, after 50 years of age, engaging in physical activity more than once a week is associated with lower odds of COVID-19 hospitalization. The protective effect of physical activity on COVID-19 hospitalization is explained by muscle strength.
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spelling pubmed-79416602021-03-10 Muscle Strength Explains the Protective Effect of Physical Activity against COVID-19 Hospitalization among Adults aged 50 Years and Older Maltagliati, Silvio Sieber, Stephen Sarrazin, Philippe Cullati, Stéphane Chalabaev, Aïna Millet, Grégoire P. Boisgontier, Matthieu P. Cheval, Boris medRxiv Article OBJECTIVES. Physical activity has been proposed as a protective factor for COVID-19 hospitalization. However, the mechanisms underlying this association are unclear. Here, we examined the association between physical activity and COVID-19 hospitalization and whether this relationship was explained by other risk factors for severe COVID-19. METHOD. We used data from adults aged 50 years and older from the Survey of Health, Ageing and Retirement in Europe. The outcome was self-reported hospitalization due to COVID-19 measured before August 2020. The main exposure was usual physical activity, self-reported between 2004 and 2017. Data were analyzed using logistic regression models. RESULTS. Among the 3139 participants included in the study (69.3 ± 8.5 years, 1763 women), 266 were tested positive for COVID-19 and 66 were hospitalized. Results showed that individuals who engaged in physical activity more than once a week had lower odds of COVID-19 hospitalization than individuals who hardly ever or never engaged in physical activity (odds ratios = 0.41, 95% confidence interval = 0.22–0.74, p = .004). This association between physical activity and COVID-19 hospitalization was explained by muscle strength, but not by other risk factors. CONCLUSION. These findings suggest that, after 50 years of age, engaging in physical activity more than once a week is associated with lower odds of COVID-19 hospitalization. The protective effect of physical activity on COVID-19 hospitalization is explained by muscle strength. Cold Spring Harbor Laboratory 2021-03-01 /pmc/articles/PMC7941660/ /pubmed/33688683 http://dx.doi.org/10.1101/2021.02.25.21252451 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Maltagliati, Silvio
Sieber, Stephen
Sarrazin, Philippe
Cullati, Stéphane
Chalabaev, Aïna
Millet, Grégoire P.
Boisgontier, Matthieu P.
Cheval, Boris
Muscle Strength Explains the Protective Effect of Physical Activity against COVID-19 Hospitalization among Adults aged 50 Years and Older
title Muscle Strength Explains the Protective Effect of Physical Activity against COVID-19 Hospitalization among Adults aged 50 Years and Older
title_full Muscle Strength Explains the Protective Effect of Physical Activity against COVID-19 Hospitalization among Adults aged 50 Years and Older
title_fullStr Muscle Strength Explains the Protective Effect of Physical Activity against COVID-19 Hospitalization among Adults aged 50 Years and Older
title_full_unstemmed Muscle Strength Explains the Protective Effect of Physical Activity against COVID-19 Hospitalization among Adults aged 50 Years and Older
title_short Muscle Strength Explains the Protective Effect of Physical Activity against COVID-19 Hospitalization among Adults aged 50 Years and Older
title_sort muscle strength explains the protective effect of physical activity against covid-19 hospitalization among adults aged 50 years and older
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941660/
https://www.ncbi.nlm.nih.gov/pubmed/33688683
http://dx.doi.org/10.1101/2021.02.25.21252451
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