C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation

Recurrent C11orf95-RELA fusions (RELA(FUS)) are the hallmark of supratentorial ependymomas. The presence of RELA as the fusion partner indicates a close association of aberrant NF-κB activity with tumorigenesis. However, the oncogenic role of the C11orf95 has not been determined. Here, we performed...

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Detalles Bibliográficos
Autores principales: Ozawa, Tatsuya, Kaneko, Syuzo, Szulzewsky, Frank, Qiao, Zhiwei, Takadera, Mutsumi, Narita, Yoshitaka, Kondo, Tadashi, Holland, Eric C., Hamamoto, Ryuji, Ichimura, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941712/
https://www.ncbi.nlm.nih.gov/pubmed/33685520
http://dx.doi.org/10.1186/s40478-021-01135-4

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