Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes

BACKGROUND: Alexander disease (AxD) is a rare neurodegenerative disorder that is caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament that is primarily expressed by astrocytes. In AxD, mutant GFAP in combination with increased GFAP expres...

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Detalles Bibliográficos
Autores principales: Boyd, Michelle M., Litscher, Suzanne J., Seitz, Laura L., Messing, Albee, Hagemann, Tracy L., Collier, Lara S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941726/
https://www.ncbi.nlm.nih.gov/pubmed/33685480
http://dx.doi.org/10.1186/s12974-021-02118-x

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