Longitudinal Monitoring of Lactate in Hospitalized and Ambulatory COVID-19 Patients

Hypoxemia is readily detectable by assessing SpO(2) levels, and these are important in optimizing COVID-19 patient management. Hyperlactatemia is a marker of tissue hypoxia, particularly in patients with increased oxygen requirement and microvascular obstruction. We monitored peripheral venous lacta...

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Detalles Bibliográficos
Autores principales: Velavan, Thirumalaisamy P., Kieu Linh, Le Thi, Kreidenweiss, Andrea, Gabor, Julian, Krishna, Sanjeev, Kremsner, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941812/
https://www.ncbi.nlm.nih.gov/pubmed/33432902
http://dx.doi.org/10.4269/ajtmh.20-1282
Descripción
Sumario:Hypoxemia is readily detectable by assessing SpO(2) levels, and these are important in optimizing COVID-19 patient management. Hyperlactatemia is a marker of tissue hypoxia, particularly in patients with increased oxygen requirement and microvascular obstruction. We monitored peripheral venous lactate concentrations in hospitalized patients with moderate to severe COVID-19 (n = 18) and in mild ambulatory COVID-19 patients in home quarantine (n = 16). Whole blood lactate decreased significantly during the clinical course and recovery in hospitalized patients (P = 0.008). The blood lactate levels were significantly higher in hospitalized patients than ambulatory patients (day 1: hospitalized versus ambulatory patients P = 0.002; day 28: hospitalized versus ambulatory patients P = < 0.0001). Elevated lactate levels may be helpful in risk stratification, and serial monitoring of lactate may prove useful in the care of hospitalized COVID-19 patients.

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