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Pyridoxal-5′-phosphate-dependent enzyme GenB3 Catalyzes C-3′,4′-dideoxygenation in gentamicin biosynthesis

BACKGROUND: The C-3′,4′-dideoxygenation structure in gentamicin can prevent deactivation by aminoglycoside 3′-phosphotransferase (APH(3′)) in drug-resistant pathogens. However, the enzyme catalyzing the dideoxygenation step in the gentamicin biosynthesis pathway remains unknown. RESULTS: Here, we re...

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Detalles Bibliográficos
Autores principales:	Zhou, Shaotong, Chen, Xiaotang, Ni, Xianpu, Liu, Yu, Zhang, Hui, Dong, Min, Xia, Huanzhang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941887/ https://www.ncbi.nlm.nih.gov/pubmed/33750386 http://dx.doi.org/10.1186/s12934-021-01558-7

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