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Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco

BACKGROUND: Toxoplasmosis is an infectious disease caused by a protozoan parasite named Toxoplasma gondii (T.gondii). Pregnant women are considered one of the risk groups. The objective of this retrospective study is to provide an updated estimate of the seroprevalence of anti-T. gondii antibodies a...

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Autores principales: Laboudi, Majda, Taghy, Zoubida, Duieb, Oussama, Peyron, François, Sadak, Abderrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941977/
https://www.ncbi.nlm.nih.gov/pubmed/33685529
http://dx.doi.org/10.1186/s41182-021-00311-5
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author Laboudi, Majda
Taghy, Zoubida
Duieb, Oussama
Peyron, François
Sadak, Abderrahim
author_facet Laboudi, Majda
Taghy, Zoubida
Duieb, Oussama
Peyron, François
Sadak, Abderrahim
author_sort Laboudi, Majda
collection PubMed
description BACKGROUND: Toxoplasmosis is an infectious disease caused by a protozoan parasite named Toxoplasma gondii (T.gondii). Pregnant women are considered one of the risk groups. The objective of this retrospective study is to provide an updated estimate of the seroprevalence of anti-T. gondii antibodies among a group of Moroccan pregnant women monitored at the Parasitology Laboratory of the National Institute of Hygiene in Rabat in Morocco. METHODS: Serum samples were tested for the presence of specific anti-T. gondii immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies using indirect enzyme-linked immunosorbent assay (ELISA). Anti-Toxoplasma IgM- and IgG-positive cases were also evaluated with the anti-Toxoplasma IgG avidity test. All cases were evaluated according to the age, parity, and historical of abortion. RESULTS: Among 677 pregnant women, 94.1% (637/677) were serologically screened for the first time and therefore had no knowledge of their serological status, and only 5.9% (40/677) were screened for the second or third time. The overall anti-T. gondii IgG and IgM seropositivity among the 637 pregnant women included in the study analysis was 43% (274/637) and 3.9% (25/637), respectively. The use of the IgG avidity test allowed excluding recent infection among 83% of cases with IgG and IgM positive sera. The mean age was 29.4 ± 6.3 years. The result of the bivariate analysis revealed that the age influenced significantly the seroprevalence rate, while the parity and the existence of previous spontaneous abortion did not have any significant statistical correlation with seropositivity to T. gondii. CONCLUSION: This study shows that 43% of pregnant women were positive and 57% of them had no antibody against the T. gondii infection. However, the pregnancy follow-up and the counseling of pregnant women remain essential for the prevention of congenital toxoplasmosis.
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spelling pubmed-79419772021-03-10 Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco Laboudi, Majda Taghy, Zoubida Duieb, Oussama Peyron, François Sadak, Abderrahim Trop Med Health Short Report BACKGROUND: Toxoplasmosis is an infectious disease caused by a protozoan parasite named Toxoplasma gondii (T.gondii). Pregnant women are considered one of the risk groups. The objective of this retrospective study is to provide an updated estimate of the seroprevalence of anti-T. gondii antibodies among a group of Moroccan pregnant women monitored at the Parasitology Laboratory of the National Institute of Hygiene in Rabat in Morocco. METHODS: Serum samples were tested for the presence of specific anti-T. gondii immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies using indirect enzyme-linked immunosorbent assay (ELISA). Anti-Toxoplasma IgM- and IgG-positive cases were also evaluated with the anti-Toxoplasma IgG avidity test. All cases were evaluated according to the age, parity, and historical of abortion. RESULTS: Among 677 pregnant women, 94.1% (637/677) were serologically screened for the first time and therefore had no knowledge of their serological status, and only 5.9% (40/677) were screened for the second or third time. The overall anti-T. gondii IgG and IgM seropositivity among the 637 pregnant women included in the study analysis was 43% (274/637) and 3.9% (25/637), respectively. The use of the IgG avidity test allowed excluding recent infection among 83% of cases with IgG and IgM positive sera. The mean age was 29.4 ± 6.3 years. The result of the bivariate analysis revealed that the age influenced significantly the seroprevalence rate, while the parity and the existence of previous spontaneous abortion did not have any significant statistical correlation with seropositivity to T. gondii. CONCLUSION: This study shows that 43% of pregnant women were positive and 57% of them had no antibody against the T. gondii infection. However, the pregnancy follow-up and the counseling of pregnant women remain essential for the prevention of congenital toxoplasmosis. BioMed Central 2021-03-08 /pmc/articles/PMC7941977/ /pubmed/33685529 http://dx.doi.org/10.1186/s41182-021-00311-5 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Report
Laboudi, Majda
Taghy, Zoubida
Duieb, Oussama
Peyron, François
Sadak, Abderrahim
Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco
title Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco
title_full Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco
title_fullStr Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco
title_full_unstemmed Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco
title_short Toxoplasma gondii seroprevalence among pregnant women in Rabat, Morocco
title_sort toxoplasma gondii seroprevalence among pregnant women in rabat, morocco
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941977/
https://www.ncbi.nlm.nih.gov/pubmed/33685529
http://dx.doi.org/10.1186/s41182-021-00311-5
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