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Six-year trend and risk factors of unsuccessful pulmonary tuberculosis treatment outcomes in Thai Community Hospital

OBJECTIVE: Tuberculosis (TB) is a major cause of morbidity and mortality globally. Despite efforts to eliminate TB in Thailand, the incidence rate has declined slowly. This study aimed to identify the incidence and risk factors of unsuccessful pulmonary TB treatment (failed, died and loss-to- follow...

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Autores principales: Charoensakulchai, Sakarn, Lertpheantum, Chaiyapun, Aksornpusitpong, Chanapon, Trakulsuk, Peeranut, Sakboonyarat, Boonsub, Rangsin, Ram, Mungthin, Mathirut, Piyaraj, Phunlerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941995/
https://www.ncbi.nlm.nih.gov/pubmed/33750450
http://dx.doi.org/10.1186/s13104-021-05504-z
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author Charoensakulchai, Sakarn
Lertpheantum, Chaiyapun
Aksornpusitpong, Chanapon
Trakulsuk, Peeranut
Sakboonyarat, Boonsub
Rangsin, Ram
Mungthin, Mathirut
Piyaraj, Phunlerd
author_facet Charoensakulchai, Sakarn
Lertpheantum, Chaiyapun
Aksornpusitpong, Chanapon
Trakulsuk, Peeranut
Sakboonyarat, Boonsub
Rangsin, Ram
Mungthin, Mathirut
Piyaraj, Phunlerd
author_sort Charoensakulchai, Sakarn
collection PubMed
description OBJECTIVE: Tuberculosis (TB) is a major cause of morbidity and mortality globally. Despite efforts to eliminate TB in Thailand, the incidence rate has declined slowly. This study aimed to identify the incidence and risk factors of unsuccessful pulmonary TB treatment (failed, died and loss-to- follow up) in a community hospital in Chachoengsao Province, Thailand from 1st January 2013 to 31st December 2019. RESULTS: A total of 487 patients were eligible for the study. The incidence of unsuccessful treatment was 21.67/100 population person year. Risk factors of unsuccessful pulmonary TB treatment were unemployment (adjusted hazard ratio (AHR) 3.12, 95%CI 1.41–6.86), HIV co-infection (AHR 2.85, 95%CI 1.25–6.46), previous history of TB (AHR 2.00, 95%CI 1.04–3.81), positive sputum AFB at the end of the intensive phase (AHR 5.66, 95%CI 2.33–13.74), and sputum AFB was not performed at the end of the intensive phase (AHR 18.40, 95%CI 9.85–34.35). This study can be utilized to improve prevention and intervention of TB treatment by strengthening public health system on treatment quality especially TB patient monitoring tools or methods easy for accessing to patients in communities. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-021-05504-z.
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spelling pubmed-79419952021-03-10 Six-year trend and risk factors of unsuccessful pulmonary tuberculosis treatment outcomes in Thai Community Hospital Charoensakulchai, Sakarn Lertpheantum, Chaiyapun Aksornpusitpong, Chanapon Trakulsuk, Peeranut Sakboonyarat, Boonsub Rangsin, Ram Mungthin, Mathirut Piyaraj, Phunlerd BMC Res Notes Research Note OBJECTIVE: Tuberculosis (TB) is a major cause of morbidity and mortality globally. Despite efforts to eliminate TB in Thailand, the incidence rate has declined slowly. This study aimed to identify the incidence and risk factors of unsuccessful pulmonary TB treatment (failed, died and loss-to- follow up) in a community hospital in Chachoengsao Province, Thailand from 1st January 2013 to 31st December 2019. RESULTS: A total of 487 patients were eligible for the study. The incidence of unsuccessful treatment was 21.67/100 population person year. Risk factors of unsuccessful pulmonary TB treatment were unemployment (adjusted hazard ratio (AHR) 3.12, 95%CI 1.41–6.86), HIV co-infection (AHR 2.85, 95%CI 1.25–6.46), previous history of TB (AHR 2.00, 95%CI 1.04–3.81), positive sputum AFB at the end of the intensive phase (AHR 5.66, 95%CI 2.33–13.74), and sputum AFB was not performed at the end of the intensive phase (AHR 18.40, 95%CI 9.85–34.35). This study can be utilized to improve prevention and intervention of TB treatment by strengthening public health system on treatment quality especially TB patient monitoring tools or methods easy for accessing to patients in communities. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-021-05504-z. BioMed Central 2021-03-09 /pmc/articles/PMC7941995/ /pubmed/33750450 http://dx.doi.org/10.1186/s13104-021-05504-z Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Charoensakulchai, Sakarn
Lertpheantum, Chaiyapun
Aksornpusitpong, Chanapon
Trakulsuk, Peeranut
Sakboonyarat, Boonsub
Rangsin, Ram
Mungthin, Mathirut
Piyaraj, Phunlerd
Six-year trend and risk factors of unsuccessful pulmonary tuberculosis treatment outcomes in Thai Community Hospital
title Six-year trend and risk factors of unsuccessful pulmonary tuberculosis treatment outcomes in Thai Community Hospital
title_full Six-year trend and risk factors of unsuccessful pulmonary tuberculosis treatment outcomes in Thai Community Hospital
title_fullStr Six-year trend and risk factors of unsuccessful pulmonary tuberculosis treatment outcomes in Thai Community Hospital
title_full_unstemmed Six-year trend and risk factors of unsuccessful pulmonary tuberculosis treatment outcomes in Thai Community Hospital
title_short Six-year trend and risk factors of unsuccessful pulmonary tuberculosis treatment outcomes in Thai Community Hospital
title_sort six-year trend and risk factors of unsuccessful pulmonary tuberculosis treatment outcomes in thai community hospital
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941995/
https://www.ncbi.nlm.nih.gov/pubmed/33750450
http://dx.doi.org/10.1186/s13104-021-05504-z
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