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Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos

PURPOSE: The aim of this study was to compare SD-OCT parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos. METHODS: Disc photos of suspicious discs with normal Humphrey visual fields (HVF) were graded as normal or pre-perimetric glaucomatous based on the...

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Autores principales: Shah, Shruti Nitin, David, Rathini Lilian, Parivadhini, Annadurai, Lingam, Vijaya, Balekudaru, Shantha, George, Ronnie Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942111/
https://www.ncbi.nlm.nih.gov/pubmed/33595484
http://dx.doi.org/10.4103/ijo.IJO_1309_20
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author Shah, Shruti Nitin
David, Rathini Lilian
Parivadhini, Annadurai
Lingam, Vijaya
Balekudaru, Shantha
George, Ronnie Jacob
author_facet Shah, Shruti Nitin
David, Rathini Lilian
Parivadhini, Annadurai
Lingam, Vijaya
Balekudaru, Shantha
George, Ronnie Jacob
author_sort Shah, Shruti Nitin
collection PubMed
description PURPOSE: The aim of this study was to compare SD-OCT parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos. METHODS: Disc photos of suspicious discs with normal Humphrey visual fields (HVF) were graded as normal or pre-perimetric glaucomatous based on the consensus of three masked glaucoma specialists. RNFL and GCL-IPL maps of SD-OCT (Cirrus OCT) of these eyes were studied. Quantitative RNFL parameters were compared. Both groups were also compared with respect to parameters being classified as abnormal (at the 1% level), and the pattern of GCL-IPL and NFL maps were assessed qualitatively and classified as normal or pre-perimetric glaucomatous by a masked glaucoma specialist. RESULTS: The average and inferior RNFL thicknesses were decreased in pre-perimetric glaucomatous eyes compared to normal eyes (p 0.01) The average, minimal, inferotemporal and inferior sector GCL-IPL thicknesses were decreased in pre-perimetric glaucomatous eyes (all P < 0.002) The highest AUC was for the inferior RNFL thickness (0.771) followed by average RNFL thickness (0.757) The sensitivity and specificity for any one abnormal RNFL parameter was 71.9% and 59.7%, for GCL-IPL parameters was 70% and 69.1% The positive (PLR) and negative likelihood ratios (NLR) were 1.78 and 0.47 for RNFL and 2.26 and 0.43 for GCL-IPL parameters. For the qualitative assessment of RNFL and GCL-IPL maps, the sensitivity, specificity, PLR and NLR were 75%, 77.2%, 3.29, and 0.32, respectively. CONCLUSION: Pre-perimetric disc suspects had greater OCT changes compared to normal disc suspects. Qualitative assessment of RNFL and GCL-IPL maps had the highest discriminatory ability.
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spelling pubmed-79421112021-03-10 Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos Shah, Shruti Nitin David, Rathini Lilian Parivadhini, Annadurai Lingam, Vijaya Balekudaru, Shantha George, Ronnie Jacob Indian J Ophthalmol Original Article PURPOSE: The aim of this study was to compare SD-OCT parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos. METHODS: Disc photos of suspicious discs with normal Humphrey visual fields (HVF) were graded as normal or pre-perimetric glaucomatous based on the consensus of three masked glaucoma specialists. RNFL and GCL-IPL maps of SD-OCT (Cirrus OCT) of these eyes were studied. Quantitative RNFL parameters were compared. Both groups were also compared with respect to parameters being classified as abnormal (at the 1% level), and the pattern of GCL-IPL and NFL maps were assessed qualitatively and classified as normal or pre-perimetric glaucomatous by a masked glaucoma specialist. RESULTS: The average and inferior RNFL thicknesses were decreased in pre-perimetric glaucomatous eyes compared to normal eyes (p 0.01) The average, minimal, inferotemporal and inferior sector GCL-IPL thicknesses were decreased in pre-perimetric glaucomatous eyes (all P < 0.002) The highest AUC was for the inferior RNFL thickness (0.771) followed by average RNFL thickness (0.757) The sensitivity and specificity for any one abnormal RNFL parameter was 71.9% and 59.7%, for GCL-IPL parameters was 70% and 69.1% The positive (PLR) and negative likelihood ratios (NLR) were 1.78 and 0.47 for RNFL and 2.26 and 0.43 for GCL-IPL parameters. For the qualitative assessment of RNFL and GCL-IPL maps, the sensitivity, specificity, PLR and NLR were 75%, 77.2%, 3.29, and 0.32, respectively. CONCLUSION: Pre-perimetric disc suspects had greater OCT changes compared to normal disc suspects. Qualitative assessment of RNFL and GCL-IPL maps had the highest discriminatory ability. Wolters Kluwer - Medknow 2021-03 2021-02-17 /pmc/articles/PMC7942111/ /pubmed/33595484 http://dx.doi.org/10.4103/ijo.IJO_1309_20 Text en Copyright: © 2021 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Shah, Shruti Nitin
David, Rathini Lilian
Parivadhini, Annadurai
Lingam, Vijaya
Balekudaru, Shantha
George, Ronnie Jacob
Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos
title Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos
title_full Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos
title_fullStr Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos
title_full_unstemmed Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos
title_short Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos
title_sort comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942111/
https://www.ncbi.nlm.nih.gov/pubmed/33595484
http://dx.doi.org/10.4103/ijo.IJO_1309_20
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