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Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos
PURPOSE: The aim of this study was to compare SD-OCT parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos. METHODS: Disc photos of suspicious discs with normal Humphrey visual fields (HVF) were graded as normal or pre-perimetric glaucomatous based on the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942111/ https://www.ncbi.nlm.nih.gov/pubmed/33595484 http://dx.doi.org/10.4103/ijo.IJO_1309_20 |
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author | Shah, Shruti Nitin David, Rathini Lilian Parivadhini, Annadurai Lingam, Vijaya Balekudaru, Shantha George, Ronnie Jacob |
author_facet | Shah, Shruti Nitin David, Rathini Lilian Parivadhini, Annadurai Lingam, Vijaya Balekudaru, Shantha George, Ronnie Jacob |
author_sort | Shah, Shruti Nitin |
collection | PubMed |
description | PURPOSE: The aim of this study was to compare SD-OCT parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos. METHODS: Disc photos of suspicious discs with normal Humphrey visual fields (HVF) were graded as normal or pre-perimetric glaucomatous based on the consensus of three masked glaucoma specialists. RNFL and GCL-IPL maps of SD-OCT (Cirrus OCT) of these eyes were studied. Quantitative RNFL parameters were compared. Both groups were also compared with respect to parameters being classified as abnormal (at the 1% level), and the pattern of GCL-IPL and NFL maps were assessed qualitatively and classified as normal or pre-perimetric glaucomatous by a masked glaucoma specialist. RESULTS: The average and inferior RNFL thicknesses were decreased in pre-perimetric glaucomatous eyes compared to normal eyes (p 0.01) The average, minimal, inferotemporal and inferior sector GCL-IPL thicknesses were decreased in pre-perimetric glaucomatous eyes (all P < 0.002) The highest AUC was for the inferior RNFL thickness (0.771) followed by average RNFL thickness (0.757) The sensitivity and specificity for any one abnormal RNFL parameter was 71.9% and 59.7%, for GCL-IPL parameters was 70% and 69.1% The positive (PLR) and negative likelihood ratios (NLR) were 1.78 and 0.47 for RNFL and 2.26 and 0.43 for GCL-IPL parameters. For the qualitative assessment of RNFL and GCL-IPL maps, the sensitivity, specificity, PLR and NLR were 75%, 77.2%, 3.29, and 0.32, respectively. CONCLUSION: Pre-perimetric disc suspects had greater OCT changes compared to normal disc suspects. Qualitative assessment of RNFL and GCL-IPL maps had the highest discriminatory ability. |
format | Online Article Text |
id | pubmed-7942111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-79421112021-03-10 Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos Shah, Shruti Nitin David, Rathini Lilian Parivadhini, Annadurai Lingam, Vijaya Balekudaru, Shantha George, Ronnie Jacob Indian J Ophthalmol Original Article PURPOSE: The aim of this study was to compare SD-OCT parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos. METHODS: Disc photos of suspicious discs with normal Humphrey visual fields (HVF) were graded as normal or pre-perimetric glaucomatous based on the consensus of three masked glaucoma specialists. RNFL and GCL-IPL maps of SD-OCT (Cirrus OCT) of these eyes were studied. Quantitative RNFL parameters were compared. Both groups were also compared with respect to parameters being classified as abnormal (at the 1% level), and the pattern of GCL-IPL and NFL maps were assessed qualitatively and classified as normal or pre-perimetric glaucomatous by a masked glaucoma specialist. RESULTS: The average and inferior RNFL thicknesses were decreased in pre-perimetric glaucomatous eyes compared to normal eyes (p 0.01) The average, minimal, inferotemporal and inferior sector GCL-IPL thicknesses were decreased in pre-perimetric glaucomatous eyes (all P < 0.002) The highest AUC was for the inferior RNFL thickness (0.771) followed by average RNFL thickness (0.757) The sensitivity and specificity for any one abnormal RNFL parameter was 71.9% and 59.7%, for GCL-IPL parameters was 70% and 69.1% The positive (PLR) and negative likelihood ratios (NLR) were 1.78 and 0.47 for RNFL and 2.26 and 0.43 for GCL-IPL parameters. For the qualitative assessment of RNFL and GCL-IPL maps, the sensitivity, specificity, PLR and NLR were 75%, 77.2%, 3.29, and 0.32, respectively. CONCLUSION: Pre-perimetric disc suspects had greater OCT changes compared to normal disc suspects. Qualitative assessment of RNFL and GCL-IPL maps had the highest discriminatory ability. Wolters Kluwer - Medknow 2021-03 2021-02-17 /pmc/articles/PMC7942111/ /pubmed/33595484 http://dx.doi.org/10.4103/ijo.IJO_1309_20 Text en Copyright: © 2021 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Shah, Shruti Nitin David, Rathini Lilian Parivadhini, Annadurai Lingam, Vijaya Balekudaru, Shantha George, Ronnie Jacob Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos |
title | Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos |
title_full | Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos |
title_fullStr | Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos |
title_full_unstemmed | Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos |
title_short | Comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos |
title_sort | comparison of spectral domain optical coherence tomography parameters between disc suspects and “pre-perimetric” glaucomatous discs classified on disc photos |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942111/ https://www.ncbi.nlm.nih.gov/pubmed/33595484 http://dx.doi.org/10.4103/ijo.IJO_1309_20 |
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