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Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19

OBJECTIVES: Previous observational studies have suggested that increased cardiac markers are commonly found in COVID-19. This study aimed to determine the relationship between several cardiac markers and the severity/mortality of COVID-19 patients. METHODS: Several cardiac markers were analysed in t...

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Autores principales: Wungu, Citrawati Dyah Kencono, Khaerunnisa, Siti, Putri, Eka Arum Cahyaning, Hidayati, Hanik Badriyah, Qurnianingsih, Ema, Lukitasari, Lina, Humairah, Ira, Soetjipto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942156/
https://www.ncbi.nlm.nih.gov/pubmed/33711519
http://dx.doi.org/10.1016/j.ijid.2021.03.008
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author Wungu, Citrawati Dyah Kencono
Khaerunnisa, Siti
Putri, Eka Arum Cahyaning
Hidayati, Hanik Badriyah
Qurnianingsih, Ema
Lukitasari, Lina
Humairah, Ira
Soetjipto
author_facet Wungu, Citrawati Dyah Kencono
Khaerunnisa, Siti
Putri, Eka Arum Cahyaning
Hidayati, Hanik Badriyah
Qurnianingsih, Ema
Lukitasari, Lina
Humairah, Ira
Soetjipto
author_sort Wungu, Citrawati Dyah Kencono
collection PubMed
description OBJECTIVES: Previous observational studies have suggested that increased cardiac markers are commonly found in COVID-19. This study aimed to determine the relationship between several cardiac markers and the severity/mortality of COVID-19 patients. METHODS: Several cardiac markers were analysed in this meta-analysis. RevMan 5.4 was used to provide pooled estimates for standardised mean difference (SMD) with 95% confidence intervals. RESULTS: Twenty-nine clinical studies were included in this meta-analysis. Significantly higher CK-MB (0.64, 95% CI = 0.19–1.09), PCT (0.47, 95% CI = 0.26−0.68), NT-proBNP (1.90, 95% CI = 1.63–2.17), BNP (1.86, 95% CI = 1.63−2.09), and d-dimer (1.30, 95% CI = 0.91−1.69) were found in severe compared with non-severe COVID-19. Significantly higher CK-MB (3.84, 95% CI = 0.62−7.05), PCT (1.49, 95% CI = 0.86−2.13), NT-proBNP (4.66, 95% CI = 2.42−6.91), BNP (1.96, 95% CI = 0.78−3.14), troponin (1.64 (95% CI = 0.83−2.45), and d-dimer (2.72, 95% CI = 2.14−3.29) were found in those who died from compared with survivors of COVID-19. CONCLUSIONS: High CK-MB, PCT, NT-proBNP, BNP, and d-dimer could be predictive markers for severity of COVID-19, while high CK-MB, PCT, NT-proBNP, BNP, troponin, and d-dimer could be predictive markers for survival of COVID-19 patients.
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spelling pubmed-79421562021-03-11 Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19 Wungu, Citrawati Dyah Kencono Khaerunnisa, Siti Putri, Eka Arum Cahyaning Hidayati, Hanik Badriyah Qurnianingsih, Ema Lukitasari, Lina Humairah, Ira Soetjipto Int J Infect Dis Article OBJECTIVES: Previous observational studies have suggested that increased cardiac markers are commonly found in COVID-19. This study aimed to determine the relationship between several cardiac markers and the severity/mortality of COVID-19 patients. METHODS: Several cardiac markers were analysed in this meta-analysis. RevMan 5.4 was used to provide pooled estimates for standardised mean difference (SMD) with 95% confidence intervals. RESULTS: Twenty-nine clinical studies were included in this meta-analysis. Significantly higher CK-MB (0.64, 95% CI = 0.19–1.09), PCT (0.47, 95% CI = 0.26−0.68), NT-proBNP (1.90, 95% CI = 1.63–2.17), BNP (1.86, 95% CI = 1.63−2.09), and d-dimer (1.30, 95% CI = 0.91−1.69) were found in severe compared with non-severe COVID-19. Significantly higher CK-MB (3.84, 95% CI = 0.62−7.05), PCT (1.49, 95% CI = 0.86−2.13), NT-proBNP (4.66, 95% CI = 2.42−6.91), BNP (1.96, 95% CI = 0.78−3.14), troponin (1.64 (95% CI = 0.83−2.45), and d-dimer (2.72, 95% CI = 2.14−3.29) were found in those who died from compared with survivors of COVID-19. CONCLUSIONS: High CK-MB, PCT, NT-proBNP, BNP, and d-dimer could be predictive markers for severity of COVID-19, while high CK-MB, PCT, NT-proBNP, BNP, troponin, and d-dimer could be predictive markers for survival of COVID-19 patients. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-04 2021-03-09 /pmc/articles/PMC7942156/ /pubmed/33711519 http://dx.doi.org/10.1016/j.ijid.2021.03.008 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wungu, Citrawati Dyah Kencono
Khaerunnisa, Siti
Putri, Eka Arum Cahyaning
Hidayati, Hanik Badriyah
Qurnianingsih, Ema
Lukitasari, Lina
Humairah, Ira
Soetjipto
Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19
title Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19
title_full Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19
title_fullStr Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19
title_full_unstemmed Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19
title_short Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19
title_sort meta-analysis of cardiac markers for predictive factors on severity and mortality of covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942156/
https://www.ncbi.nlm.nih.gov/pubmed/33711519
http://dx.doi.org/10.1016/j.ijid.2021.03.008
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