ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway

Recently, COVID-19 caused by the novel coronavirus SARS-CoV-2 has brought great challenges to the world. More and more studies have shown that patients with severe COVID-19 may suffer from cytokine storm syndrome; however, there are few studies on its pathogenesis. Here we demonstrated that SARS-CoV...

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Detalles Bibliográficos
Autores principales: Lin, Xiaoyuan, Fu, Beibei, Yin, Songna, Li, Zhifeng, Liu, Huawen, Zhang, Haiwei, Xing, Na, Wang, Yu, Xue, Weiwei, Xiong, Yan, Zhang, Shanfu, Zhao, Qingting, Xu, Shiyao, Zhang, Jing, Wang, Peihui, Nian, Weiqi, Wang, Xingsheng, Wu, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942160/
https://www.ncbi.nlm.nih.gov/pubmed/33723527
http://dx.doi.org/10.1016/j.isci.2021.102293
Descripción
Sumario:Recently, COVID-19 caused by the novel coronavirus SARS-CoV-2 has brought great challenges to the world. More and more studies have shown that patients with severe COVID-19 may suffer from cytokine storm syndrome; however, there are few studies on its pathogenesis. Here we demonstrated that SARS-CoV-2 coding protein open reading frame 8 (ORF8) acted as a contributing factor to cytokine storm during COVID-19 infection. ORF8 could activate IL-17 signaling pathway and promote the expression of pro-inflammatory factors. Moreover, we demonstrated that treatment of IL17RA antibody protected mice from ORF8-induced inflammation. Our findings are helpful to understand the pathogenesis of cytokine storm caused by SARS-CoV-2 and provide a potential target for the development of COVID-19 therapeutic drugs.

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