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Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis
Chronic inflammation of the male genital tract is thought to be a primary etiological factor of male infertility. The abundance and activation of macrophages and dendritic cells in patients with chronic inflammation of genital tract were closely associated with oligozoospermia and asthenospermia. Ch...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942197/ https://www.ncbi.nlm.nih.gov/pubmed/33708220 http://dx.doi.org/10.3389/fimmu.2021.629680 |
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author | Zheng, Wenzhong Zhang, Shiqiang Chen, Xiaobao Jiang, Shaoqin Li, Zhihao Li, Mengqiang |
author_facet | Zheng, Wenzhong Zhang, Shiqiang Chen, Xiaobao Jiang, Shaoqin Li, Zhihao Li, Mengqiang |
author_sort | Zheng, Wenzhong |
collection | PubMed |
description | Chronic inflammation of the male genital tract is thought to be a primary etiological factor of male infertility. The abundance and activation of macrophages and dendritic cells in patients with chronic inflammation of genital tract were closely associated with oligozoospermia and asthenospermia. Chronic epididymitis appears to be more important than seminal vesiculitis or prostatitis due to the direct interaction between spermatozoa and epididymal inflammatory cells. In this study, we present a case report of a 41-year-old male with oligoasthenospermia and chronic epididymitis. Hematoxylin-eosin staining and immunofluorescence analyses showed that antigen presenting cells including macrophages and dendritic cells were found capturing spermatozoa in the lumen of cauda epididymis. To our knowledge, this is the first case report that directly observed dendritic cells capturing spermatozoa in the lumen of an inflamed epididymis. This finding directly explains chronic epididymitis as the possible cause of oligospermia in patients. |
format | Online Article Text |
id | pubmed-7942197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79421972021-03-10 Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis Zheng, Wenzhong Zhang, Shiqiang Chen, Xiaobao Jiang, Shaoqin Li, Zhihao Li, Mengqiang Front Immunol Immunology Chronic inflammation of the male genital tract is thought to be a primary etiological factor of male infertility. The abundance and activation of macrophages and dendritic cells in patients with chronic inflammation of genital tract were closely associated with oligozoospermia and asthenospermia. Chronic epididymitis appears to be more important than seminal vesiculitis or prostatitis due to the direct interaction between spermatozoa and epididymal inflammatory cells. In this study, we present a case report of a 41-year-old male with oligoasthenospermia and chronic epididymitis. Hematoxylin-eosin staining and immunofluorescence analyses showed that antigen presenting cells including macrophages and dendritic cells were found capturing spermatozoa in the lumen of cauda epididymis. To our knowledge, this is the first case report that directly observed dendritic cells capturing spermatozoa in the lumen of an inflamed epididymis. This finding directly explains chronic epididymitis as the possible cause of oligospermia in patients. Frontiers Media S.A. 2021-02-23 /pmc/articles/PMC7942197/ /pubmed/33708220 http://dx.doi.org/10.3389/fimmu.2021.629680 Text en Copyright © 2021 Zheng, Zhang, Chen, Jiang, Li and Li http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zheng, Wenzhong Zhang, Shiqiang Chen, Xiaobao Jiang, Shaoqin Li, Zhihao Li, Mengqiang Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis |
title | Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis |
title_full | Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis |
title_fullStr | Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis |
title_full_unstemmed | Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis |
title_short | Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis |
title_sort | case report: dendritic cells and macrophages capture sperm in chronically inflamed human epididymis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942197/ https://www.ncbi.nlm.nih.gov/pubmed/33708220 http://dx.doi.org/10.3389/fimmu.2021.629680 |
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