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Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis

Chronic inflammation of the male genital tract is thought to be a primary etiological factor of male infertility. The abundance and activation of macrophages and dendritic cells in patients with chronic inflammation of genital tract were closely associated with oligozoospermia and asthenospermia. Ch...

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Autores principales: Zheng, Wenzhong, Zhang, Shiqiang, Chen, Xiaobao, Jiang, Shaoqin, Li, Zhihao, Li, Mengqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942197/
https://www.ncbi.nlm.nih.gov/pubmed/33708220
http://dx.doi.org/10.3389/fimmu.2021.629680
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author Zheng, Wenzhong
Zhang, Shiqiang
Chen, Xiaobao
Jiang, Shaoqin
Li, Zhihao
Li, Mengqiang
author_facet Zheng, Wenzhong
Zhang, Shiqiang
Chen, Xiaobao
Jiang, Shaoqin
Li, Zhihao
Li, Mengqiang
author_sort Zheng, Wenzhong
collection PubMed
description Chronic inflammation of the male genital tract is thought to be a primary etiological factor of male infertility. The abundance and activation of macrophages and dendritic cells in patients with chronic inflammation of genital tract were closely associated with oligozoospermia and asthenospermia. Chronic epididymitis appears to be more important than seminal vesiculitis or prostatitis due to the direct interaction between spermatozoa and epididymal inflammatory cells. In this study, we present a case report of a 41-year-old male with oligoasthenospermia and chronic epididymitis. Hematoxylin-eosin staining and immunofluorescence analyses showed that antigen presenting cells including macrophages and dendritic cells were found capturing spermatozoa in the lumen of cauda epididymis. To our knowledge, this is the first case report that directly observed dendritic cells capturing spermatozoa in the lumen of an inflamed epididymis. This finding directly explains chronic epididymitis as the possible cause of oligospermia in patients.
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spelling pubmed-79421972021-03-10 Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis Zheng, Wenzhong Zhang, Shiqiang Chen, Xiaobao Jiang, Shaoqin Li, Zhihao Li, Mengqiang Front Immunol Immunology Chronic inflammation of the male genital tract is thought to be a primary etiological factor of male infertility. The abundance and activation of macrophages and dendritic cells in patients with chronic inflammation of genital tract were closely associated with oligozoospermia and asthenospermia. Chronic epididymitis appears to be more important than seminal vesiculitis or prostatitis due to the direct interaction between spermatozoa and epididymal inflammatory cells. In this study, we present a case report of a 41-year-old male with oligoasthenospermia and chronic epididymitis. Hematoxylin-eosin staining and immunofluorescence analyses showed that antigen presenting cells including macrophages and dendritic cells were found capturing spermatozoa in the lumen of cauda epididymis. To our knowledge, this is the first case report that directly observed dendritic cells capturing spermatozoa in the lumen of an inflamed epididymis. This finding directly explains chronic epididymitis as the possible cause of oligospermia in patients. Frontiers Media S.A. 2021-02-23 /pmc/articles/PMC7942197/ /pubmed/33708220 http://dx.doi.org/10.3389/fimmu.2021.629680 Text en Copyright © 2021 Zheng, Zhang, Chen, Jiang, Li and Li http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zheng, Wenzhong
Zhang, Shiqiang
Chen, Xiaobao
Jiang, Shaoqin
Li, Zhihao
Li, Mengqiang
Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis
title Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis
title_full Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis
title_fullStr Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis
title_full_unstemmed Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis
title_short Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis
title_sort case report: dendritic cells and macrophages capture sperm in chronically inflamed human epididymis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942197/
https://www.ncbi.nlm.nih.gov/pubmed/33708220
http://dx.doi.org/10.3389/fimmu.2021.629680
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