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What’s new in chronic pain pathophysiology

The understanding of pain pathophysiology is continuously evolving. Identifying underlying cellular and subcellular pathways helps create opportunities for targeted therapies that may prove to be effective interventions. This article is an update on four areas of developing knowledge as it pertains...

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Detalles Bibliográficos
Autores principales: Cohen, Ivan, Lema, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942794/
https://www.ncbi.nlm.nih.gov/pubmed/33987515
http://dx.doi.org/10.1080/24740527.2020.1752641
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author Cohen, Ivan
Lema, Mark J.
author_facet Cohen, Ivan
Lema, Mark J.
author_sort Cohen, Ivan
collection PubMed
description The understanding of pain pathophysiology is continuously evolving. Identifying underlying cellular and subcellular pathways helps create opportunities for targeted therapies that may prove to be effective interventions. This article is an update on four areas of developing knowledge as it pertains to clinical management of patients with pain: nerve growth factor antagonists, microglial modulation, AMP-activated protein kinase activators, and genetic pain factors. Each of these areas represents novel targets for targeted therapies to prevent, treat, and modify the disease course of acute, chronic, and neuropathic pain. Currently most pain management techniques do not target these pathways directly, but there is promising evidence to suggest that the field is advancing toward available therapies in the near future.
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spelling pubmed-79427942021-05-12 What’s new in chronic pain pathophysiology Cohen, Ivan Lema, Mark J. Can J Pain Review The understanding of pain pathophysiology is continuously evolving. Identifying underlying cellular and subcellular pathways helps create opportunities for targeted therapies that may prove to be effective interventions. This article is an update on four areas of developing knowledge as it pertains to clinical management of patients with pain: nerve growth factor antagonists, microglial modulation, AMP-activated protein kinase activators, and genetic pain factors. Each of these areas represents novel targets for targeted therapies to prevent, treat, and modify the disease course of acute, chronic, and neuropathic pain. Currently most pain management techniques do not target these pathways directly, but there is promising evidence to suggest that the field is advancing toward available therapies in the near future. Taylor & Francis 2020-12-30 /pmc/articles/PMC7942794/ /pubmed/33987515 http://dx.doi.org/10.1080/24740527.2020.1752641 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Cohen, Ivan
Lema, Mark J.
What’s new in chronic pain pathophysiology
title What’s new in chronic pain pathophysiology
title_full What’s new in chronic pain pathophysiology
title_fullStr What’s new in chronic pain pathophysiology
title_full_unstemmed What’s new in chronic pain pathophysiology
title_short What’s new in chronic pain pathophysiology
title_sort what’s new in chronic pain pathophysiology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942794/
https://www.ncbi.nlm.nih.gov/pubmed/33987515
http://dx.doi.org/10.1080/24740527.2020.1752641
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