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Ventilator-associated pneumonia among ICU patients in WHO Southeast Asian region: A systematic review

Ventilator-associated pneumonia (VAP) is one of the most frequent ICU-acquired infections and a leading cause of death among patients in Intensive Care Unit (ICU). The South East Asian Region is a part of the world with limited health resources where infectious diseases are still underestimated. We...

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Autores principales: Kharel, Sanjeev, Bist, Anil, Mishra, Shyam Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942996/
https://www.ncbi.nlm.nih.gov/pubmed/33690663
http://dx.doi.org/10.1371/journal.pone.0247832
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author Kharel, Sanjeev
Bist, Anil
Mishra, Shyam Kumar
author_facet Kharel, Sanjeev
Bist, Anil
Mishra, Shyam Kumar
author_sort Kharel, Sanjeev
collection PubMed
description Ventilator-associated pneumonia (VAP) is one of the most frequent ICU-acquired infections and a leading cause of death among patients in Intensive Care Unit (ICU). The South East Asian Region is a part of the world with limited health resources where infectious diseases are still underestimated. We aimed to review the literature in this part of the world to describe incidence, mortality and microbiological evidence of VAP and explore preventive and control strategies. We selected 24 peer-reviewed articles published from January 1, 2000 to September 1, 2020 from electronic databases and manual searching for observational studies among adult patients diagnosed with VAP expressed per thousand days admitted in ICU. The VAP rates ranged from 2.13 to 116 per thousand days, varying among different countries of this region. A significant rate of mortality was observed in 13 studies ranging from 16.2% to 74.1%. Gram negative organisms like Acinetobacter spp., Pseudomonas aeruginosa and Klebsiella pneumoniae and Gram-positive organisms like Staphylococcus aureus and Enterococcus species were frequently found. Our findings suggest an alarming situation of VAP among patients of most of the countries of this region with increasing incidence, mortality and antibiotic resistance. Thus, there is an urgent need for cost effective control and preventive measures like interventional studies and educational programs on staff training, hand hygiene, awareness on antibiotic resistance, implementation of antibiotic stewardship programs and appropriate use of ventilator bundle approach.
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spelling pubmed-79429962021-03-19 Ventilator-associated pneumonia among ICU patients in WHO Southeast Asian region: A systematic review Kharel, Sanjeev Bist, Anil Mishra, Shyam Kumar PLoS One Research Article Ventilator-associated pneumonia (VAP) is one of the most frequent ICU-acquired infections and a leading cause of death among patients in Intensive Care Unit (ICU). The South East Asian Region is a part of the world with limited health resources where infectious diseases are still underestimated. We aimed to review the literature in this part of the world to describe incidence, mortality and microbiological evidence of VAP and explore preventive and control strategies. We selected 24 peer-reviewed articles published from January 1, 2000 to September 1, 2020 from electronic databases and manual searching for observational studies among adult patients diagnosed with VAP expressed per thousand days admitted in ICU. The VAP rates ranged from 2.13 to 116 per thousand days, varying among different countries of this region. A significant rate of mortality was observed in 13 studies ranging from 16.2% to 74.1%. Gram negative organisms like Acinetobacter spp., Pseudomonas aeruginosa and Klebsiella pneumoniae and Gram-positive organisms like Staphylococcus aureus and Enterococcus species were frequently found. Our findings suggest an alarming situation of VAP among patients of most of the countries of this region with increasing incidence, mortality and antibiotic resistance. Thus, there is an urgent need for cost effective control and preventive measures like interventional studies and educational programs on staff training, hand hygiene, awareness on antibiotic resistance, implementation of antibiotic stewardship programs and appropriate use of ventilator bundle approach. Public Library of Science 2021-03-09 /pmc/articles/PMC7942996/ /pubmed/33690663 http://dx.doi.org/10.1371/journal.pone.0247832 Text en © 2021 Kharel et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kharel, Sanjeev
Bist, Anil
Mishra, Shyam Kumar
Ventilator-associated pneumonia among ICU patients in WHO Southeast Asian region: A systematic review
title Ventilator-associated pneumonia among ICU patients in WHO Southeast Asian region: A systematic review
title_full Ventilator-associated pneumonia among ICU patients in WHO Southeast Asian region: A systematic review
title_fullStr Ventilator-associated pneumonia among ICU patients in WHO Southeast Asian region: A systematic review
title_full_unstemmed Ventilator-associated pneumonia among ICU patients in WHO Southeast Asian region: A systematic review
title_short Ventilator-associated pneumonia among ICU patients in WHO Southeast Asian region: A systematic review
title_sort ventilator-associated pneumonia among icu patients in who southeast asian region: a systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942996/
https://www.ncbi.nlm.nih.gov/pubmed/33690663
http://dx.doi.org/10.1371/journal.pone.0247832
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