Cargando…

Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation

Liquid-liquid phase separation (LLPS) can drive formation of diverse and essential macromolecular structures, including those specified by viruses. Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) genomes associate with the viral encoded Latency-Associated Nuclear Antigen (LANA) to form stable nuclear...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vladimirova, Olga, De Leo, Alessandra, Deng, Zhong, Wiedmer, Andreas, Hayden, James, Lieberman, Paul M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943007/ https://www.ncbi.nlm.nih.gov/pubmed/33471863 http://dx.doi.org/10.1371/journal.ppat.1009231

Ejemplares similares

LANA oligomeric architecture is essential for KSHV nuclear body formation and viral genome maintenance during latency
por: De Leo, Alessandra, et al.
Publicado: (2019)

KSHV LANA—The Master Regulator of KSHV Latency
por: Uppal, Timsy, et al.
Publicado: (2014)

KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA
por: Cheng, Fang, et al.
Publicado: (2009)

MLL1 is regulated by KSHV LANA and is important for virus latency
por: Tan, Min, et al.
Publicado: (2021)

Induction of KSHV latency-associated nuclear antigen (LANA) by hypoxia and hypoxia-inducible factors (HIF)
por: Veeranna, Ravindra P, et al.
Publicado: (2012)

A Unique SUMO-2-Interacting Motif within LANA Is Essential for KSHV Latency
por: Cai, Qiliang, et al.
Publicado: (2013)

Molecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANA
por: Domsic, John F., et al.
Publicado: (2013)

Phosphorylation of the Chromatin Binding Domain of KSHV LANA
por: Woodard, Crystal, et al.
Publicado: (2012)

Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA
por: Wei, Fang, et al.
Publicado: (2016)

KSHV-encoded LANA protects the cellular replication machinery from hypoxia induced degradation
por: Singh, Rajnish Kumar, et al.
Publicado: (2019)

Regulation of KSHV Latency and Lytic Reactivation
por: Broussard, Grant, et al.
Publicado: (2020)

Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy
por: Lang, Fengchao, et al.
Publicado: (2018)

Correction: Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy
por: Lang, Fengchao, et al.
Publicado: (2019)

Antibody epitope profiling of the KSHV LANA protein using VirScan
por: Bennett, Sydney J., et al.
Publicado: (2022)

BET-Inhibitors Disrupt Rad21-Dependent Conformational Control of KSHV Latency
por: Chen, Horng-Shen, et al.
Publicado: (2017)

Deregulation of KSHV latency conformation by ER-stress and caspase-dependent RAD21-cleavage
por: De Leo, Alessandra, et al.
Publicado: (2017)

Conservation of Complex Nuclear Localization Signals Utilizing Classical and Non-Classical Nuclear Import Pathways in LANA Homologs of KSHV and RFHV
por: Cherezova, Lidia, et al.
Publicado: (2011)

Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency
por: Mariggiò, Giuseppe, et al.
Publicado: (2017)

Correction: Deregulation of KSHV latency conformation by ER-stress and caspase-dependent RAD21-cleavage
por: De Leo, Alessandra, et al.
Publicado: (2018)

KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence
por: Juillard, Franceline, et al.
Publicado: (2020)

Upregulation of Cell Surface Glycoproteins in Correlation with KSHV LANA in the Kaposi Sarcoma Tumor Microenvironment
por: Privatt, Sara R., et al.
Publicado: (2023)

KSHV LANA upregulates the expression of epidermal growth factor like domain 7 to promote angiogenesis
por: Thakker, Suhani, et al.
Publicado: (2017)

RTA and LANA Competitively Regulate let-7a/RBPJ Signal to Control KSHV Replication
por: Di, Chunhong, et al.
Publicado: (2022)

DAXX-ATRX regulation of p53 chromatin binding and DNA damage response
por: Gulve, Nitish, et al.
Publicado: (2022)

IRF-4-Mediated CIITA Transcription Is Blocked by KSHV Encoded LANA to Inhibit MHC II Presentation
por: Cai, Qiliang, et al.
Publicado: (2013)

Mitochondrial protein, TBRG4, modulates KSHV and EBV reactivation from latency
por: Zhang, Huirong, et al.
Publicado: (2022)

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA
por: Ponnusamy, Rajesh, et al.
Publicado: (2015)

LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection
por: Toth, Zsolt, et al.
Publicado: (2016)

Proteomic Profiling Identifies Kaposi’s Sarcoma-Associated Herpesvirus (KSHV)-Encoded LANA(SIM)-Associated Proteins in Hypoxia
por: Liu, Xiaoqing, et al.
Publicado: (2021)

Macrophages drive KSHV B cell latency
por: Szymula, Agnieszka, et al.
Publicado: (2023)

Latently KSHV-Infected Cells Promote Further Establishment of Latency upon Superinfection with KSHV
por: Gam ze Letova, Chen, et al.
Publicado: (2021)

EC(5)S Ubiquitin Complex Is Recruited by KSHV Latent Antigen LANA for Degradation of the VHL and p53 Tumor Suppressors
por: Cai, Qi-Liang, et al.
Publicado: (2006)

Coordination of KSHV Latent and Lytic Gene Control by CTCF-Cohesin Mediated Chromosome Conformation
por: Kang, Hyojeung, et al.
Publicado: (2011)

NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency
por: Ma, Zhe, et al.
Publicado: (2017)

KSHV encoded LANA recruits Nucleosome Assembly Protein NAP1L1 for regulating viral DNA replication and transcription
por: Gupta, Namrata, et al.
Publicado: (2016)

CTCF Prevents the Epigenetic Drift of EBV Latency Promoter Qp
por: Tempera, Italo, et al.
Publicado: (2010)

CERN lana site
Publicado: (2009)

Aholoa Lāna‘i!
por: Kealoha, May K.
Publicado: (2020)

KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice
por: Sin, Sang-Hoon, et al.
Publicado: (2015)

Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1
por: Ishov, Alexander M., et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_k50a0qb4h9hkvta5q9gs3leote