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Maternal and Neonatal Outcomes of COVID-19 in Pregnancy: A Single-Centre Observational Study

Background: The current coronavirus disease 2019 (COVID-19) pandemic is one of the most challenging healthcare crises faced globally. Adequate information and understanding of the clinical presentation and impact of the disease on maternal and neonatal outcomes is the key to successfully manage a pr...

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Autores principales: Singh, Vinita, Choudhary, Anisha, Datta, Mamta R, Ray, Alokananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943051/
https://www.ncbi.nlm.nih.gov/pubmed/33717728
http://dx.doi.org/10.7759/cureus.13184
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author Singh, Vinita
Choudhary, Anisha
Datta, Mamta R
Ray, Alokananda
author_facet Singh, Vinita
Choudhary, Anisha
Datta, Mamta R
Ray, Alokananda
author_sort Singh, Vinita
collection PubMed
description Background: The current coronavirus disease 2019 (COVID-19) pandemic is one of the most challenging healthcare crises faced globally. Adequate information and understanding of the clinical presentation and impact of the disease on maternal and neonatal outcomes is the key to successfully manage a pregnancy with COVID-19. Objective: The purpose of the present study was to evaluate the clinical presentation of COVID-19 in pregnancy, its course during pregnancy and its effects on maternal and neonatal outcomes. Study design and setting: This study was a retrospective observational study conducted at Tata Main Hospital, Jamshedpur, a tertiary care hospital in Eastern India. Population and study period: All COVID-19-positive (by reverse transcription polymerase chain reaction or rapid antigen test) pregnant women admitted to the hospital from 15(th )May 2020 to 15(th) November 2020.  Results: A total of 132 COVID-19-positive pregnant women were included in the study. Eighty-six women (65.15%) were asymptomatic, 45 women (34.09%) had mild symptoms and one woman had severe disease. Major co-morbidities seen were hypertensive disorders (pre-eclampsia, gestational hypertension and chronic hypertension) in 18 (13.64%) and diabetes (gestational diabetes, diabetes mellitus type 2) in 14women (10.60%). The rate of preterm delivery was 28.69% (n=35). Caesarean section was done for 78 women (63.93%) and 44 (36.07%) delivered vaginally. Average birth weight reported was 2.59 kilograms. Forty babies (33.06%) were admitted to the neonatal intensive care unit. Two babies (1.65%) tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within 24 hours of delivery.  Conclusion: COVID-19 in pregnancy commonly presents as an asymptomatic or mild disease. It is associated with high rates of preterm births and neonatal admissions to the intensive care unit. Intrauterine and neonatal death rates remain low. Vertical transmission is possible; however, the incidence is low, and the majority of these neonates are asymptomatic.
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spelling pubmed-79430512021-03-12 Maternal and Neonatal Outcomes of COVID-19 in Pregnancy: A Single-Centre Observational Study Singh, Vinita Choudhary, Anisha Datta, Mamta R Ray, Alokananda Cureus Obstetrics/Gynecology Background: The current coronavirus disease 2019 (COVID-19) pandemic is one of the most challenging healthcare crises faced globally. Adequate information and understanding of the clinical presentation and impact of the disease on maternal and neonatal outcomes is the key to successfully manage a pregnancy with COVID-19. Objective: The purpose of the present study was to evaluate the clinical presentation of COVID-19 in pregnancy, its course during pregnancy and its effects on maternal and neonatal outcomes. Study design and setting: This study was a retrospective observational study conducted at Tata Main Hospital, Jamshedpur, a tertiary care hospital in Eastern India. Population and study period: All COVID-19-positive (by reverse transcription polymerase chain reaction or rapid antigen test) pregnant women admitted to the hospital from 15(th )May 2020 to 15(th) November 2020.  Results: A total of 132 COVID-19-positive pregnant women were included in the study. Eighty-six women (65.15%) were asymptomatic, 45 women (34.09%) had mild symptoms and one woman had severe disease. Major co-morbidities seen were hypertensive disorders (pre-eclampsia, gestational hypertension and chronic hypertension) in 18 (13.64%) and diabetes (gestational diabetes, diabetes mellitus type 2) in 14women (10.60%). The rate of preterm delivery was 28.69% (n=35). Caesarean section was done for 78 women (63.93%) and 44 (36.07%) delivered vaginally. Average birth weight reported was 2.59 kilograms. Forty babies (33.06%) were admitted to the neonatal intensive care unit. Two babies (1.65%) tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within 24 hours of delivery.  Conclusion: COVID-19 in pregnancy commonly presents as an asymptomatic or mild disease. It is associated with high rates of preterm births and neonatal admissions to the intensive care unit. Intrauterine and neonatal death rates remain low. Vertical transmission is possible; however, the incidence is low, and the majority of these neonates are asymptomatic. Cureus 2021-02-06 /pmc/articles/PMC7943051/ /pubmed/33717728 http://dx.doi.org/10.7759/cureus.13184 Text en Copyright © 2021, Singh et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Obstetrics/Gynecology
Singh, Vinita
Choudhary, Anisha
Datta, Mamta R
Ray, Alokananda
Maternal and Neonatal Outcomes of COVID-19 in Pregnancy: A Single-Centre Observational Study
title Maternal and Neonatal Outcomes of COVID-19 in Pregnancy: A Single-Centre Observational Study
title_full Maternal and Neonatal Outcomes of COVID-19 in Pregnancy: A Single-Centre Observational Study
title_fullStr Maternal and Neonatal Outcomes of COVID-19 in Pregnancy: A Single-Centre Observational Study
title_full_unstemmed Maternal and Neonatal Outcomes of COVID-19 in Pregnancy: A Single-Centre Observational Study
title_short Maternal and Neonatal Outcomes of COVID-19 in Pregnancy: A Single-Centre Observational Study
title_sort maternal and neonatal outcomes of covid-19 in pregnancy: a single-centre observational study
topic Obstetrics/Gynecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943051/
https://www.ncbi.nlm.nih.gov/pubmed/33717728
http://dx.doi.org/10.7759/cureus.13184
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