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Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection

A hallmark of adaptive immunity is CD4 T cells’ ability to differentiate into specialized effectors. A long-standing question is whether T cell receptor (TCR) signal strength can dominantly instruct the development of Th1 and T follicular helper (Tfh) cells across distinct infectious contexts. We ch...

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Detalles Bibliográficos
Autores principales:	Künzli, Marco, Reuther, Peter, Pinschewer, Daniel D, King, Carolyn G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943189/ https://www.ncbi.nlm.nih.gov/pubmed/33684030 http://dx.doi.org/10.7554/eLife.61869

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