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Controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: Practical issues
In Korean women, a westernized lifestyle is associated with an increased risk of breast cancer. Fertility preservation has become an increasingly important issue for women with breast cancer, in accordance with substantial improvements in survival rate after cancer treatment. The methods of controll...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Reproductive Medicine
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943346/ https://www.ncbi.nlm.nih.gov/pubmed/33131234 http://dx.doi.org/10.5653/cerm.2020.03594 |
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author | Park, So Yun Jeong, Kyungah Cho, Eun Hye Chung, Hye Won |
author_facet | Park, So Yun Jeong, Kyungah Cho, Eun Hye Chung, Hye Won |
author_sort | Park, So Yun |
collection | PubMed |
description | In Korean women, a westernized lifestyle is associated with an increased risk of breast cancer. Fertility preservation has become an increasingly important issue for women with breast cancer, in accordance with substantial improvements in survival rate after cancer treatment. The methods of controlled ovarian hyperstimulation (COH) for fertility preservation in breast cancer patients have been modified to include aromatase inhibitors to reduce the potential harm associated with increased estradiol levels. Random-start COH and dual ovarian stimulation are feasible options to reduce the total duration of fertility preservation treatment and to efficiently collect oocytes or embryos. Using a gonadotropin-releasing hormone agonist as a trigger may improve cycle outcomes in breast cancer patients undergoing COH for fertility preservation. In young breast cancer patients with BRCA mutations, especially BRCA1 mutations, the possibility of diminished ovarian reserve may be considered, although further studies are necessary. Herein, we review the current literature on the practical issues surrounding COH for fertility preservation in women with breast cancer. |
format | Online Article Text |
id | pubmed-7943346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society for Reproductive Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-79433462021-03-18 Controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: Practical issues Park, So Yun Jeong, Kyungah Cho, Eun Hye Chung, Hye Won Clin Exp Reprod Med Review Article In Korean women, a westernized lifestyle is associated with an increased risk of breast cancer. Fertility preservation has become an increasingly important issue for women with breast cancer, in accordance with substantial improvements in survival rate after cancer treatment. The methods of controlled ovarian hyperstimulation (COH) for fertility preservation in breast cancer patients have been modified to include aromatase inhibitors to reduce the potential harm associated with increased estradiol levels. Random-start COH and dual ovarian stimulation are feasible options to reduce the total duration of fertility preservation treatment and to efficiently collect oocytes or embryos. Using a gonadotropin-releasing hormone agonist as a trigger may improve cycle outcomes in breast cancer patients undergoing COH for fertility preservation. In young breast cancer patients with BRCA mutations, especially BRCA1 mutations, the possibility of diminished ovarian reserve may be considered, although further studies are necessary. Herein, we review the current literature on the practical issues surrounding COH for fertility preservation in women with breast cancer. Korean Society for Reproductive Medicine 2021-03 2020-11-02 /pmc/articles/PMC7943346/ /pubmed/33131234 http://dx.doi.org/10.5653/cerm.2020.03594 Text en Copyright © 2021. THE KOREAN SOCIETY FOR REPRODUCTIVE MEDICINE This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Park, So Yun Jeong, Kyungah Cho, Eun Hye Chung, Hye Won Controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: Practical issues |
title | Controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: Practical issues |
title_full | Controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: Practical issues |
title_fullStr | Controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: Practical issues |
title_full_unstemmed | Controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: Practical issues |
title_short | Controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: Practical issues |
title_sort | controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: practical issues |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943346/ https://www.ncbi.nlm.nih.gov/pubmed/33131234 http://dx.doi.org/10.5653/cerm.2020.03594 |
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