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Sensitivity and elasticity analysis of novel corona virus transmission model: A mathematical approach

The deadly corona virus continues to pound the globe mercilessly compelling mathematical models and computational simulations which might prove effective tools to enable global efforts to estimate key transmission parameters involved in the system. We propose a mathematical model using a set of non-...

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Autores principales: Das, Kalyan, Ranjith Kumar, G., Madhusudhan Reddy, K., Lakshminarayan, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943394/
https://www.ncbi.nlm.nih.gov/pubmed/34766050
http://dx.doi.org/10.1016/j.sintl.2021.100088
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author Das, Kalyan
Ranjith Kumar, G.
Madhusudhan Reddy, K.
Lakshminarayan, K.
author_facet Das, Kalyan
Ranjith Kumar, G.
Madhusudhan Reddy, K.
Lakshminarayan, K.
author_sort Das, Kalyan
collection PubMed
description The deadly corona virus continues to pound the globe mercilessly compelling mathematical models and computational simulations which might prove effective tools to enable global efforts to estimate key transmission parameters involved in the system. We propose a mathematical model using a set of non-linear differential equations to account for the spread of the COVID-19 infection with special compartment class isolation or quarantine and estimate the model parameters by fitting the model with reported data of the ongoing pandemic situation in India. The basic reproduction number is defined and local stability analysis is carried out at each equilibrium point in terms of the reproduction number [Formula: see text]. The model is fitted mathematically and makes the data India specific. Additionally, we examined sensitivity analysis of the model. These outcomes recommend how to control the spread of corona, keeping in mind contact and recovery rate. Also we have investigated the elasticity of the basic reproduction number as a measure of control parameters of the dynamical system. Numerical simulations were also done to show that the proposed model is valid for the type and spread of the outbreak which happened in India.
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spelling pubmed-79433942021-03-11 Sensitivity and elasticity analysis of novel corona virus transmission model: A mathematical approach Das, Kalyan Ranjith Kumar, G. Madhusudhan Reddy, K. Lakshminarayan, K. Sens Int Article The deadly corona virus continues to pound the globe mercilessly compelling mathematical models and computational simulations which might prove effective tools to enable global efforts to estimate key transmission parameters involved in the system. We propose a mathematical model using a set of non-linear differential equations to account for the spread of the COVID-19 infection with special compartment class isolation or quarantine and estimate the model parameters by fitting the model with reported data of the ongoing pandemic situation in India. The basic reproduction number is defined and local stability analysis is carried out at each equilibrium point in terms of the reproduction number [Formula: see text]. The model is fitted mathematically and makes the data India specific. Additionally, we examined sensitivity analysis of the model. These outcomes recommend how to control the spread of corona, keeping in mind contact and recovery rate. Also we have investigated the elasticity of the basic reproduction number as a measure of control parameters of the dynamical system. Numerical simulations were also done to show that the proposed model is valid for the type and spread of the outbreak which happened in India. The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. 2021 2021-03-10 /pmc/articles/PMC7943394/ /pubmed/34766050 http://dx.doi.org/10.1016/j.sintl.2021.100088 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Das, Kalyan
Ranjith Kumar, G.
Madhusudhan Reddy, K.
Lakshminarayan, K.
Sensitivity and elasticity analysis of novel corona virus transmission model: A mathematical approach
title Sensitivity and elasticity analysis of novel corona virus transmission model: A mathematical approach
title_full Sensitivity and elasticity analysis of novel corona virus transmission model: A mathematical approach
title_fullStr Sensitivity and elasticity analysis of novel corona virus transmission model: A mathematical approach
title_full_unstemmed Sensitivity and elasticity analysis of novel corona virus transmission model: A mathematical approach
title_short Sensitivity and elasticity analysis of novel corona virus transmission model: A mathematical approach
title_sort sensitivity and elasticity analysis of novel corona virus transmission model: a mathematical approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943394/
https://www.ncbi.nlm.nih.gov/pubmed/34766050
http://dx.doi.org/10.1016/j.sintl.2021.100088
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