Biological Function of HYOU1 in Tumors and Other Diseases

Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many d...

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Detalles Bibliográficos
Autores principales: Rao, Shan, Oyang, Linda, Liang, Jiaxin, Yi, Pin, Han, Yaqian, Luo, Xia, Xia, Longzheng, Lin, Jinguan, Tan, Shiming, Hu, Jiaqi, Wang, Hui, Tang, Lu, Pan, Qing, Tang, Yanyan, Zhou, Yujuan, Liao, Qianjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943547/
https://www.ncbi.nlm.nih.gov/pubmed/33707955
http://dx.doi.org/10.2147/OTT.S297332
Descripción
Sumario:Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many diseases, including various cancers and endoplasmic reticulum stress-related diseases. HYOU1 does not only play an important protective role in the occurrence and development of tumors, but also is a potential therapeutic target for cancer. HYOU1 may also be used as an immune stimulation adjuvant because of its anti-tumor immune response, and a molecular target for therapy of many endoplasmic reticulum-related diseases. In this article, we summarize the updates in HYOU1 and discuss the potential therapeutic effects of HYOU1.

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