Biological Function of HYOU1 in Tumors and Other Diseases

Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many d...

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Autores principales: Rao, Shan, Oyang, Linda, Liang, Jiaxin, Yi, Pin, Han, Yaqian, Luo, Xia, Xia, Longzheng, Lin, Jinguan, Tan, Shiming, Hu, Jiaqi, Wang, Hui, Tang, Lu, Pan, Qing, Tang, Yanyan, Zhou, Yujuan, Liao, Qianjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943547/
https://www.ncbi.nlm.nih.gov/pubmed/33707955
http://dx.doi.org/10.2147/OTT.S297332
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author Rao, Shan
Oyang, Linda
Liang, Jiaxin
Yi, Pin
Han, Yaqian
Luo, Xia
Xia, Longzheng
Lin, Jinguan
Tan, Shiming
Hu, Jiaqi
Wang, Hui
Tang, Lu
Pan, Qing
Tang, Yanyan
Zhou, Yujuan
Liao, Qianjin
author_facet Rao, Shan
Oyang, Linda
Liang, Jiaxin
Yi, Pin
Han, Yaqian
Luo, Xia
Xia, Longzheng
Lin, Jinguan
Tan, Shiming
Hu, Jiaqi
Wang, Hui
Tang, Lu
Pan, Qing
Tang, Yanyan
Zhou, Yujuan
Liao, Qianjin
author_sort Rao, Shan
collection PubMed
description Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many diseases, including various cancers and endoplasmic reticulum stress-related diseases. HYOU1 does not only play an important protective role in the occurrence and development of tumors, but also is a potential therapeutic target for cancer. HYOU1 may also be used as an immune stimulation adjuvant because of its anti-tumor immune response, and a molecular target for therapy of many endoplasmic reticulum-related diseases. In this article, we summarize the updates in HYOU1 and discuss the potential therapeutic effects of HYOU1.
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spelling pubmed-79435472021-03-10 Biological Function of HYOU1 in Tumors and Other Diseases Rao, Shan Oyang, Linda Liang, Jiaxin Yi, Pin Han, Yaqian Luo, Xia Xia, Longzheng Lin, Jinguan Tan, Shiming Hu, Jiaqi Wang, Hui Tang, Lu Pan, Qing Tang, Yanyan Zhou, Yujuan Liao, Qianjin Onco Targets Ther Review Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many diseases, including various cancers and endoplasmic reticulum stress-related diseases. HYOU1 does not only play an important protective role in the occurrence and development of tumors, but also is a potential therapeutic target for cancer. HYOU1 may also be used as an immune stimulation adjuvant because of its anti-tumor immune response, and a molecular target for therapy of many endoplasmic reticulum-related diseases. In this article, we summarize the updates in HYOU1 and discuss the potential therapeutic effects of HYOU1. Dove 2021-03-05 /pmc/articles/PMC7943547/ /pubmed/33707955 http://dx.doi.org/10.2147/OTT.S297332 Text en © 2021 Rao et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Rao, Shan
Oyang, Linda
Liang, Jiaxin
Yi, Pin
Han, Yaqian
Luo, Xia
Xia, Longzheng
Lin, Jinguan
Tan, Shiming
Hu, Jiaqi
Wang, Hui
Tang, Lu
Pan, Qing
Tang, Yanyan
Zhou, Yujuan
Liao, Qianjin
Biological Function of HYOU1 in Tumors and Other Diseases
title Biological Function of HYOU1 in Tumors and Other Diseases
title_full Biological Function of HYOU1 in Tumors and Other Diseases
title_fullStr Biological Function of HYOU1 in Tumors and Other Diseases
title_full_unstemmed Biological Function of HYOU1 in Tumors and Other Diseases
title_short Biological Function of HYOU1 in Tumors and Other Diseases
title_sort biological function of hyou1 in tumors and other diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943547/
https://www.ncbi.nlm.nih.gov/pubmed/33707955
http://dx.doi.org/10.2147/OTT.S297332
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