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Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring
To develop individualized motor rehabilitation, knowledge of the relationship between neuroplastic reorganization and motor recovery after pediatric arterial ischemic stroke (AIS) is crucial. Thus, we investigated functional connectivity in patients after AIS with good motor outcome and in patients...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943570/ https://www.ncbi.nlm.nih.gov/pubmed/33750854 http://dx.doi.org/10.1038/s41598-021-84671-2 |
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author | Steiner, Leonie Homan, Stephanie Everts, Regula Federspiel, Andrea Kamal, Sandeep Rodriguez, Juan Antonio Delgado Kornfeld, Salome Slavova, Nedelina Wiest, Roland Kaelin-Lang, Alain Steinlin, Maja Grunt, Sebastian |
author_facet | Steiner, Leonie Homan, Stephanie Everts, Regula Federspiel, Andrea Kamal, Sandeep Rodriguez, Juan Antonio Delgado Kornfeld, Salome Slavova, Nedelina Wiest, Roland Kaelin-Lang, Alain Steinlin, Maja Grunt, Sebastian |
author_sort | Steiner, Leonie |
collection | PubMed |
description | To develop individualized motor rehabilitation, knowledge of the relationship between neuroplastic reorganization and motor recovery after pediatric arterial ischemic stroke (AIS) is crucial. Thus, we investigated functional connectivity in patients after AIS with good motor outcome and in patients with hemiparesis compared with typically developing peers. We included 18 patients (n = 9 with hemiparesis, n = 9 with good motor outcome) with pediatric AIS in the chronic phase (≥ 2 years after diagnosis, diagnosed > 16 years) and 18 peers matched by age and gender. Participants underwent a standardized motor assessment, single-pulse transcranial magnetic stimulation to determine the type of corticospinal tract wiring, and resting-state functional magnetic resonance imaging to examine motor network connectivity. Corticospinal tract wiring was contralateral in all participants. Patients with hemiparesis had lower interhemispheric connectivity strength compared with patients with good clinical outcome and peers. Patients with good clinical outcome had higher intrahemispheric connectivity strength compared with peers. Further, higher intrahemispheric connectivity was related to better motor outcome in patients. Our findings suggest that better motor outcome after pediatric AIS is related to higher motor network connectivity strength. Thus, resting-state functional connectivity might be predictive for motor recovery after pediatric AIS. |
format | Online Article Text |
id | pubmed-7943570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79435702021-03-10 Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring Steiner, Leonie Homan, Stephanie Everts, Regula Federspiel, Andrea Kamal, Sandeep Rodriguez, Juan Antonio Delgado Kornfeld, Salome Slavova, Nedelina Wiest, Roland Kaelin-Lang, Alain Steinlin, Maja Grunt, Sebastian Sci Rep Article To develop individualized motor rehabilitation, knowledge of the relationship between neuroplastic reorganization and motor recovery after pediatric arterial ischemic stroke (AIS) is crucial. Thus, we investigated functional connectivity in patients after AIS with good motor outcome and in patients with hemiparesis compared with typically developing peers. We included 18 patients (n = 9 with hemiparesis, n = 9 with good motor outcome) with pediatric AIS in the chronic phase (≥ 2 years after diagnosis, diagnosed > 16 years) and 18 peers matched by age and gender. Participants underwent a standardized motor assessment, single-pulse transcranial magnetic stimulation to determine the type of corticospinal tract wiring, and resting-state functional magnetic resonance imaging to examine motor network connectivity. Corticospinal tract wiring was contralateral in all participants. Patients with hemiparesis had lower interhemispheric connectivity strength compared with patients with good clinical outcome and peers. Patients with good clinical outcome had higher intrahemispheric connectivity strength compared with peers. Further, higher intrahemispheric connectivity was related to better motor outcome in patients. Our findings suggest that better motor outcome after pediatric AIS is related to higher motor network connectivity strength. Thus, resting-state functional connectivity might be predictive for motor recovery after pediatric AIS. Nature Publishing Group UK 2021-03-09 /pmc/articles/PMC7943570/ /pubmed/33750854 http://dx.doi.org/10.1038/s41598-021-84671-2 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Steiner, Leonie Homan, Stephanie Everts, Regula Federspiel, Andrea Kamal, Sandeep Rodriguez, Juan Antonio Delgado Kornfeld, Salome Slavova, Nedelina Wiest, Roland Kaelin-Lang, Alain Steinlin, Maja Grunt, Sebastian Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring |
title | Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring |
title_full | Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring |
title_fullStr | Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring |
title_full_unstemmed | Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring |
title_short | Functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring |
title_sort | functional connectivity and upper limb function in patients after pediatric arterial ischemic stroke with contralateral corticospinal tract wiring |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943570/ https://www.ncbi.nlm.nih.gov/pubmed/33750854 http://dx.doi.org/10.1038/s41598-021-84671-2 |
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