Structural resolution of switchable states of a de novo peptide assembly

De novo protein design is advancing rapidly. However, most designs are for single states. Here we report a de novo designed peptide that forms multiple α-helical-bundle states that are accessible and interconvertible under the same conditions. Usually in such designs amphipathic α helices associate...

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Detalles Bibliográficos
Autores principales: Dawson, William M., Lang, Eric J. M., Rhys, Guto G., Shelley, Kathryn L., Williams, Christopher, Brady, R. Leo, Crump, Matthew P., Mulholland, Adrian J., Woolfson, Derek N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943578/
https://www.ncbi.nlm.nih.gov/pubmed/33750792
http://dx.doi.org/10.1038/s41467-021-21851-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943578/
https://www.ncbi.nlm.nih.gov/pubmed/33750792
http://dx.doi.org/10.1038/s41467-021-21851-8

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