Cargando…
The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450 (CYP) epoxygenases, which include four regioisomers: 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. Each of them possesses beneficial effects against inflammation, fibrosis, and apoptosis, which could combat cardiov...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943617/ https://www.ncbi.nlm.nih.gov/pubmed/33716791 http://dx.doi.org/10.3389/fphys.2021.642470 |
_version_ | 1783662534607241216 |
---|---|
author | Lai, Jinsheng Chen, Chen |
author_facet | Lai, Jinsheng Chen, Chen |
author_sort | Lai, Jinsheng |
collection | PubMed |
description | Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450 (CYP) epoxygenases, which include four regioisomers: 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. Each of them possesses beneficial effects against inflammation, fibrosis, and apoptosis, which could combat cardiovascular diseases. Numerous studies have demonstrated that elevation of EETs by overexpression of CYP2J2, inhibition of sEH, or treatment with EET analogs showed protective effects in various cardiovascular diseases, including hypertension, myocardial infarction, and heart failure. As is known to all, cardiac remodeling is the major pathogenesis of cardiovascular diseases. This review will begin with the introduction of EETs and their protective effects in cardiovascular diseases. In the following, the roles of EETs in cardiac remodeling, with a particular emphasis on myocardial hypertrophy, apoptosis, fibrosis, inflammation, and angiogenesis, will be summarized. Finally, it is suggested that upregulation of EETs is a potential therapeutic strategy for cardiovascular diseases. The EET-related drug development against cardiac remodeling is also discussed, including the overexpression of CYP2J2, inhibition of sEH, and the analogs of EET. |
format | Online Article Text |
id | pubmed-7943617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79436172021-03-11 The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling Lai, Jinsheng Chen, Chen Front Physiol Physiology Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450 (CYP) epoxygenases, which include four regioisomers: 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. Each of them possesses beneficial effects against inflammation, fibrosis, and apoptosis, which could combat cardiovascular diseases. Numerous studies have demonstrated that elevation of EETs by overexpression of CYP2J2, inhibition of sEH, or treatment with EET analogs showed protective effects in various cardiovascular diseases, including hypertension, myocardial infarction, and heart failure. As is known to all, cardiac remodeling is the major pathogenesis of cardiovascular diseases. This review will begin with the introduction of EETs and their protective effects in cardiovascular diseases. In the following, the roles of EETs in cardiac remodeling, with a particular emphasis on myocardial hypertrophy, apoptosis, fibrosis, inflammation, and angiogenesis, will be summarized. Finally, it is suggested that upregulation of EETs is a potential therapeutic strategy for cardiovascular diseases. The EET-related drug development against cardiac remodeling is also discussed, including the overexpression of CYP2J2, inhibition of sEH, and the analogs of EET. Frontiers Media S.A. 2021-02-24 /pmc/articles/PMC7943617/ /pubmed/33716791 http://dx.doi.org/10.3389/fphys.2021.642470 Text en Copyright © 2021 Lai and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Lai, Jinsheng Chen, Chen The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling |
title | The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling |
title_full | The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling |
title_fullStr | The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling |
title_full_unstemmed | The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling |
title_short | The Role of Epoxyeicosatrienoic Acids in Cardiac Remodeling |
title_sort | role of epoxyeicosatrienoic acids in cardiac remodeling |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943617/ https://www.ncbi.nlm.nih.gov/pubmed/33716791 http://dx.doi.org/10.3389/fphys.2021.642470 |
work_keys_str_mv | AT laijinsheng theroleofepoxyeicosatrienoicacidsincardiacremodeling AT chenchen theroleofepoxyeicosatrienoicacidsincardiacremodeling AT laijinsheng roleofepoxyeicosatrienoicacidsincardiacremodeling AT chenchen roleofepoxyeicosatrienoicacidsincardiacremodeling |