Cargando…

A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis

BACKGROUND: Osteoarthritis (OA) is a disease with multiple endotypes. A hallmark of OA is loss of cartilage; however, it is evident that the rate of cartilage loss differs among patients, which may partly be attributed to differential capacity for cartilage repair. We hypothesize that a low cartilag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Yunyun, Samuels, Jonathan, Krasnokutsky, Svetlana, Byrjalsen, Inger, Kraus, Virginia B., He, Yi, Karsdal, Morten A., Abramson, Steven B., Attur, Mukundan, Bay-Jensen, Anne C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943687/ https://www.ncbi.nlm.nih.gov/pubmed/33687578 http://dx.doi.org/10.1186/s10195-021-00572-0

Ejemplares similares

The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis
por: Attur, Mukundan, et al.
Publicado: (2020)

Vascular Adhesion Protein-1 (VAP-1) as Predictor of Radiographic Severity in Symptomatic Knee Osteoarthritis in the New York University Cohort
por: Bournazou, Eirini, et al.
Publicado: (2019)

Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations
por: Attur, Mukundan, et al.
Publicado: (2009)

Age-dependent ferritin elevations and HFE C282Y mutation as risk factors for symptomatic knee osteoarthritis in males: a longitudinal cohort study
por: Kennish, Lauren, et al.
Publicado: (2014)

Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease
por: Attur, Mukundan, et al.
Publicado: (2020)

Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis
por: Bihlet, Asger Reinstrup, et al.
Publicado: (2019)

Pathological tissue formation and degradation biomarkers correlate with patient reported pain outcomes: an explorative study
por: Bay-Jensen, Anne C., et al.
Publicado: (2023)

Developments in the scientific understanding of osteoarthritis
por: Abramson, Steven B, et al.
Publicado: (2009)

Blood and urine biomarkers in osteoarthritis – an update on cartilage associated type II collagen and aggrecan markers
por: Bay-Jensen, Anne C., et al.
Publicado: (2022)

Periostin interaction with discoidin domain receptor-1 (DDR1) promotes cartilage degeneration
por: Han, Tianzhen, et al.
Publicado: (2020)

Paracrine pathways of cartilage destruction in osteoarthritis
por: Abramson, S, et al.
Publicado: (2003)

Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis
por: Bihlet, Asger Reinstrup, et al.
Publicado: (2018)

Diagnosis of Osteoarthritis by Cartilage Surface Smoothness Quantified Automatically from Knee MRI
por: Tummala, Sudhakar, et al.
Publicado: (2011)

Circulating Protein Fragments of Cartilage and Connective Tissue Degradation Are Diagnostic and Prognostic Markers of Rheumatoid Arthritis and Ankylosing Spondylitis
por: Bay-Jensen, Anne C., et al.
Publicado: (2013)

Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis - the effect of sex, Kellgren-Lawrence (KL) score, Body Mass Index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation
por: Karsdal, MA, et al.
Publicado: (2010)

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women
por: Kluzek, Stefan, et al.
Publicado: (2015)

Periostin loss-of-function protects mice from post-traumatic and age-related osteoarthritis
por: Attur, Mukundan, et al.
Publicado: (2021)

Role of Intestinal Dysbiosis and Nutrition in Rheumatoid Arthritis
por: Attur, Malavikalakshmi, et al.
Publicado: (2022)

The minor collagens in articular cartilage
por: Luo, Yunyun, et al.
Publicado: (2017)

Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
por: Bay-Jensen, Anne-Christine, et al.
Publicado: (2021)

Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: considerations for event driven clinical trial design
por: Bager, Cecilie L., et al.
Publicado: (2019)

Does increased local bone resorption secondary to breast and prostate cancer result in increased cartilage degradation?
por: Leeming, Diana J, et al.
Publicado: (2008)

Identification of progressors in osteoarthritis by combining biochemical and MRI-based markers
por: Dam, Erik B, et al.
Publicado: (2009)

Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation
por: Karsdal, MA, et al.
Publicado: (2008)

Serological Biomarkers of Joint Tissue Turnover Predict Tocilizumab Response at Baseline
por: Bay-Jensen, Anne C., et al.
Publicado: (2014)

Early changes in blood-based joint tissue destruction biomarkers are predictive of response to tocilizumab in the LITHE study
por: Bay-Jensen, Anne C., et al.
Publicado: (2016)

A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis
por: Alexander, Louie C., et al.
Publicado: (2021)

Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult
por: Tan, Andrea R., et al.
Publicado: (2015)

Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: The effect of water and timing of meal intake on oral delivery of Salmon Calcitonin
por: Karsdal, Morten A, et al.
Publicado: (2008)

The Effect of Protease Inhibitors on the Induction of Osteoarthritis-Related Biomarkers in Bovine Full-Depth Cartilage Explants
por: He, Yi, et al.
Publicado: (2015)

The Efficacy and Safety of Multiple Dose Regimens of Kudzu (Pueraria lobata) Root Extract on Bone and Cartilage Turnover and Menopausal Symptoms
por: Bihlet, Asger Reinstrup, et al.
Publicado: (2021)

Endotypes of primary osteoarthritis identified by plasma metabolomics analysis
por: Werdyani, Salem, et al.
Publicado: (2020)

PLCL1 rs7595412 variation is not associated with hip bone size variation in postmenopausal Danish women
por: Cauchi, Stéphane, et al.
Publicado: (2009)

Bone and cartilage characteristics in postmenopausal women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis
por: Multanen, J., et al.
Publicado: (2015)

Evaluation of serum ARGS neoepitope as an osteoarthritis biomarker using a standardized model for exercise-induced cartilage extra cellular matrix turnover
por: Bjerre-Bastos, Jonathan J., et al.
Publicado: (2020)

Genicular artery embolization for treatment of knee osteoarthritis pain: Systematic review and meta-analysis
por: Taslakian, Bedros, et al.
Publicado: (2023)

Tissue metabolite of type I collagen, C1M, and CRP predicts structural progression of rheumatoid arthritis
por: Bay-Jensen, Anne C., et al.
Publicado: (2019)

A serological type II collagen neoepitope biomarker reflects cartilage breakdown in patients with osteoarthritis
por: Groen, Solveig Skovlund, et al.
Publicado: (2021)

Is radiographic progression in radiographic axial spondyloarthritis related to matrix metalloproteinase degradation of extracellular matrix?
por: Siebuhr, Anne Sofie, et al.
Publicado: (2018)

Identification of pathological RA endotypes using blood-based biomarkers reflecting tissue metabolism. A retrospective and explorative analysis of two phase III RA studies
por: Blair, J. P. M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qaqdsq0cjb4q4hnopr9pg9r6mj