DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells

Mutation of the DNAJC12 gene is typically associated with non-progressive Parkinsonism, but is also detectable in breast carcinoma where its contribution and mechanisms are unexplored. In breast carcinoma, ESR1 was positively correlated with DNAJC12 and ERBB4, and DNAJC12 was positively correlated w...

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Autores principales: Lin, Mianjie, Wang, Ya-Nan, Ye, Yixin, Xiong, Zhelei, Guo, Fengbiao, Chen, Haibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943744/
https://www.ncbi.nlm.nih.gov/pubmed/33718139
http://dx.doi.org/10.3389/fonc.2021.582277
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author Lin, Mianjie
Wang, Ya-Nan
Ye, Yixin
Xiong, Zhelei
Guo, Fengbiao
Chen, Haibin
author_facet Lin, Mianjie
Wang, Ya-Nan
Ye, Yixin
Xiong, Zhelei
Guo, Fengbiao
Chen, Haibin
author_sort Lin, Mianjie
collection PubMed
description Mutation of the DNAJC12 gene is typically associated with non-progressive Parkinsonism, but is also detectable in breast carcinoma where its contribution and mechanisms are unexplored. In breast carcinoma, ESR1 was positively correlated with DNAJC12 and ERBB4, and DNAJC12 was positively correlated with ERBB4. We used the GEO2R tool to compare differential gene expression of MCF-7 cells, following ESR1 knockdown (GEO database, E-GEOD-27473 array), and found decreased expression of DNAJC12 and ERBB4 in ESR1-silenced MCF-7 cells. The number of identical genes having correlativity with ESR1, DNAJC12, or ERBB4 was 12,165 (66.41%). These results suggest that ESR1 can promote the expression of DNAJC12 and ERBB4, and DNAJC12 can enhance the expression of ERBB4 in MCF-7 cells, implying that there may be a regulatory network among these three genes.
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spelling pubmed-79437442021-03-11 DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells Lin, Mianjie Wang, Ya-Nan Ye, Yixin Xiong, Zhelei Guo, Fengbiao Chen, Haibin Front Oncol Oncology Mutation of the DNAJC12 gene is typically associated with non-progressive Parkinsonism, but is also detectable in breast carcinoma where its contribution and mechanisms are unexplored. In breast carcinoma, ESR1 was positively correlated with DNAJC12 and ERBB4, and DNAJC12 was positively correlated with ERBB4. We used the GEO2R tool to compare differential gene expression of MCF-7 cells, following ESR1 knockdown (GEO database, E-GEOD-27473 array), and found decreased expression of DNAJC12 and ERBB4 in ESR1-silenced MCF-7 cells. The number of identical genes having correlativity with ESR1, DNAJC12, or ERBB4 was 12,165 (66.41%). These results suggest that ESR1 can promote the expression of DNAJC12 and ERBB4, and DNAJC12 can enhance the expression of ERBB4 in MCF-7 cells, implying that there may be a regulatory network among these three genes. Frontiers Media S.A. 2021-02-24 /pmc/articles/PMC7943744/ /pubmed/33718139 http://dx.doi.org/10.3389/fonc.2021.582277 Text en Copyright © 2021 Lin, Wang, Ye, Xiong, Guo and Chen http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lin, Mianjie
Wang, Ya-Nan
Ye, Yixin
Xiong, Zhelei
Guo, Fengbiao
Chen, Haibin
DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells
title DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells
title_full DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells
title_fullStr DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells
title_full_unstemmed DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells
title_short DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells
title_sort dnajc12 as a mediator between esr1 and erbb4 in breast carcinoma cells
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943744/
https://www.ncbi.nlm.nih.gov/pubmed/33718139
http://dx.doi.org/10.3389/fonc.2021.582277
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